Introduction to Luminogenic bioprobes for personal health technologies

For many years, biological markers have been considered to be one of the most critical components for monitoring patients’ health. They can be used to measure the state of patients, provide feedback for the effective application of treatment strategies or evaluate everyday processes, pathogenic processes or pharmacological responses to therapeutic intervention. Organic luminogenic bioprobes provide robust and powerful analytical techniques for the direct detection and monitoring of important biological markers in various bodily fluids including saliva, blood, urine or sweat samples. In contrast to conventional fluorophores with the aggregation-caused quenching effect, aggregation-induced emission luminogens (AIEgens) exhibit remarkable photophysical properties such as bright fluorescence in the aggregate or solid state, large Stokes shifts, excellent photostability and long retention time in live samples. Benefiting from these advantages, AIEgen-based bioprobes are widely applied in various biomedical areas. The rapid and widespread rollout of low-cost, accurate AIEgen applications can pick up disease biomarkers at very low concentrations.