Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

Matthew Sinnott, Paul Cleary, John Arkwright, Philip Dinning

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Complex relationships exist between gut contractility and the flow of digesta. We propose here a Smoothed Particle Hydrodynamics model coupling the flow of luminal content and wall flexure to help investigate these relationships. The model indicates that a zone of muscular relaxation preceding the contraction is an important element for transport. Low pressures in this zone generate positive thrust for low viscosity content. The viscosity of luminal content controls the localization of the flow and the magnitude of the radial pressure gradient and together with contraction amplitude they control the transport rate. For high viscosity content, high lumen occlusion is required for effective propulsion.

    Original languageEnglish
    Pages (from-to)492-503
    Number of pages12
    JournalComputers in Biology and Medicine
    Volume42
    Issue number4
    DOIs
    Publication statusPublished - 2012

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