Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome P450 enzymes: A Molecular Dynamics study

Pramod Nair; John Miners

Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome P450 enzymes: A Molecular Dynamics study

College of Medicine and Public Health

Research output: Contribution to conference › Abstract › peer-review

Abstract

Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ...

Original language	English
Publication status	Published - 2014
Event	5th FIP Pharmaceutical Sciences World Congress - Duration: 13 Apr 2014 → …

Conference

Conference	5th FIP Pharmaceutical Sciences World Congress
Period	13/04/14 → …

Cite this

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abstract = "Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ...",

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AU - Miners, John

PY - 2014

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N2 - Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ...

AB - Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ...

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M3 - Abstract

Y2 - 13 April 2014

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Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome P450 enzymes: A Molecular Dynamics study

Abstract

Conference

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