Investigation of hemodynamics in individualized aneurysm based on computational fluid Dynamics/Finite Element Method/CT

Aneurysm is one of essential cardiovascular and cerebrovascular diseases, and endovascular interventional neuroradiology has become the effective approach in clinical treatment, so the rupture and its prevention of aneurysm is one of prospective research in biomechanics in the 21st century. As shown in clinical investigation, WSS (wall shear stress) and pressure/velocity of blood flow have played an important role in the growth and rupture of aneurysm. It is important to evaluate how about the bloodstream impacting forces and the local pressure elevation at the aneurysm especially, considering patients individual difference. Comparing with current aneurysm hemodynamic researches, corresponding fundamental studies are presented, for example, numerical simulation of blood flow in aneurysm with the help of CFD, fluid-structure interaction model of FEM, and 3D reconstruction of biologic tissues based on CT, so on. Obtained results indicate that geometrical configuration of aneurysm and vessel, pulsating flow in inlet, interaction between blood flow and deformation of vessel have important influence on hemodynamics of aneurysm. Thus, using fluid-structure interaction model, numerical simulation of blood flow in aneurysm based on CT must be the prospective direction in future.