TY - JOUR
T1 - Ion movements in cell death
T2 - From protection to execution
AU - Barros, Luis Felipe
AU - Castro, Joel
AU - Bittner, Carla X.
PY - 2002/10/30
Y1 - 2002/10/30
N2 - Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+l and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers.
AB - Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+l and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers.
KW - Apoptosis
KW - Cell death
KW - Membrane channels
KW - Necrosis
UR - http://www.scopus.com/inward/record.url?scp=0036400640&partnerID=8YFLogxK
U2 - 10.4067/S0716-97602002000200012
DO - 10.4067/S0716-97602002000200012
M3 - Article
C2 - 12415738
AN - SCOPUS:0036400640
VL - 35
SP - 209
EP - 214
JO - BIOLOGICAL RESEARCH
JF - BIOLOGICAL RESEARCH
SN - 0716-9760
IS - 2
ER -