Is there a role for estrogen and progesterone receptors in gall bladder cancer?

P. J. Shukla, S. G. Barreto, P. Gupta, R. Neve, M. Ramadwar, K. Deodhar, Shaesta Mehta, S. V. Shrikhande, K. M. Mohandas

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background/Aims. The concept of metaplastic and non-metaplastic types of gall bladder cancer and the likelihood of hormone receptor expression in the nuclei of tumour cells raised the possibility of a potential role for anti-estrogen therapy in gall bladder cancer. This study was carried out to determine the hormone receptors (ER/PR) expression level in gall bladder cancer using specific immunohistochemical assays and correlate it with patient and tumour histopathological characteristics. Patients and methods. Histopathological tumour specimens of 62 patients who underwent a radical cholecystectomy were analysed. Pronase pretreatment and primary monoclonal antibodies were used to perform immunohistochemical analysis for ER and PR. Results. The histology was adenocarcinoma - predominantly, moderately to poorly differentiated (91%). Gallstones were present in 90% of the individuals. Of the 62 specimens analysed, 62 (100%) and 61 (98%) were negative for ER and PR, respectively. Conclusion. The high incidence of gallstone-related gall bladder cancer in India is associated with metaplasia and a tendency to poorer differentiation in the tumour histology. These tumours are consequently less likely to express hormone receptors. Thus, there does not seem to be a role for anti-hormone therapy in patients with histogenesis similar to that seen in India.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
Issue number4
Publication statusPublished - Aug 2007
Externally publishedYes


  • Estrogen receptor
  • Gall bladder cancer
  • Immunohistochemistry
  • Progesterone receptor


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