Islets and pancreatic ductal adenocarcinoma – An opportunity for translational research from the ‘Bench to the Bedside’

Savio G. Barreto; Michael Z. Michael; Damien J. Keating

doi:10.1016/j.pan.2020.02.001

Islets and pancreatic ductal adenocarcinoma – An opportunity for translational research from the ‘Bench to the Bedside’

Savio G. Barreto, Michael Z. Michael, Damien J. Keating

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

The islet-acinar axis is of prime importance to the optimal functioning of the human pancreas. Not only is this inter-relationship important for normal physiological processes, it is also relevant in diseased states, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Early experiments, nearly 4 decades ago, explored the role of islets in the development and progression of PDAC. These led to further studies that provided compelling evidence to support the role of islets and their hormones in PDAC. This association presents oncologists with therapeutic options not only for managing, but potentially preventing PDAC, a cancer that is well known for its poor patient outcomes. This review will discuss the accumulated evidence regarding the role of islets and their hormones in PDAC and highlight areas for future research.

Original language	English
Pages (from-to)	385-390
Number of pages	6
Journal	Pancreatology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.pan.2020.02.001
Publication status	Published - Apr 2020

Keywords

Endocrine
Exocrine
Glucagon
Insulin
Somatostatin

Access to Document

10.1016/j.pan.2020.02.001Licence: In Copyright

Cite this

@article{99251c344c0841199243d41c7cf4a113,

title = "Islets and pancreatic ductal adenocarcinoma – An opportunity for translational research from the {\textquoteleft}Bench to the Bedside{\textquoteright}",

abstract = "The islet-acinar axis is of prime importance to the optimal functioning of the human pancreas. Not only is this inter-relationship important for normal physiological processes, it is also relevant in diseased states, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Early experiments, nearly 4 decades ago, explored the role of islets in the development and progression of PDAC. These led to further studies that provided compelling evidence to support the role of islets and their hormones in PDAC. This association presents oncologists with therapeutic options not only for managing, but potentially preventing PDAC, a cancer that is well known for its poor patient outcomes. This review will discuss the accumulated evidence regarding the role of islets and their hormones in PDAC and highlight areas for future research.",

keywords = "Endocrine, Exocrine, Glucagon, Insulin, Somatostatin",

author = "Barreto, {Savio G.} and Michael, {Michael Z.} and Keating, {Damien J.}",

year = "2020",

month = apr,

doi = "10.1016/j.pan.2020.02.001",

language = "English",

volume = "20",

pages = "385--390",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Islets and pancreatic ductal adenocarcinoma – An opportunity for translational research from the ‘Bench to the Bedside’

AU - Barreto, Savio G.

AU - Michael, Michael Z.

AU - Keating, Damien J.

PY - 2020/4

Y1 - 2020/4

N2 - The islet-acinar axis is of prime importance to the optimal functioning of the human pancreas. Not only is this inter-relationship important for normal physiological processes, it is also relevant in diseased states, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Early experiments, nearly 4 decades ago, explored the role of islets in the development and progression of PDAC. These led to further studies that provided compelling evidence to support the role of islets and their hormones in PDAC. This association presents oncologists with therapeutic options not only for managing, but potentially preventing PDAC, a cancer that is well known for its poor patient outcomes. This review will discuss the accumulated evidence regarding the role of islets and their hormones in PDAC and highlight areas for future research.

AB - The islet-acinar axis is of prime importance to the optimal functioning of the human pancreas. Not only is this inter-relationship important for normal physiological processes, it is also relevant in diseased states, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Early experiments, nearly 4 decades ago, explored the role of islets in the development and progression of PDAC. These led to further studies that provided compelling evidence to support the role of islets and their hormones in PDAC. This association presents oncologists with therapeutic options not only for managing, but potentially preventing PDAC, a cancer that is well known for its poor patient outcomes. This review will discuss the accumulated evidence regarding the role of islets and their hormones in PDAC and highlight areas for future research.

KW - Endocrine

KW - Exocrine

KW - Glucagon

KW - Insulin

KW - Somatostatin

UR - http://www.scopus.com/inward/record.url?scp=85079136733&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2020.02.001

DO - 10.1016/j.pan.2020.02.001

M3 - Review article

C2 - 32057682

AN - SCOPUS:85079136733

SN - 1424-3903

VL - 20

SP - 385

EP - 390

JO - Pancreatology

JF - Pancreatology

IS - 3

ER -

Islets and pancreatic ductal adenocarcinoma – An opportunity for translational research from the ‘Bench to the Bedside’

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this