Abstract
(Figure Presented) Not bad at all: A simple biological circuit composed of two integrated molecular switches was developed for the detection and amplification of a specific nucleic acid in a biological extract. The nucleic acid is recognized by a molecular beacon, then a DNA polymerase and nicking endonuclease are used to rapidly amplify the signal for sensitive detection of the nucleic acid.
Original language | English |
---|---|
Pages (from-to) | 2720-2723 |
Number of pages | 4 |
Journal | Angewandte Chemie-International Edition |
Volume | 49 |
Issue number | 15 |
DOIs | |
Publication status | Published - 1 Apr 2010 |
Keywords
- Biosensors
- DNA detection
- DNA nanomachines
- Molecular devices
- Nanobiotechnology