Isothermal detection of DNA by beacon-assisted detection amplification.

Ashley Connolly; Matt Trau

doi:10.1002/anie.200906992

Isothermal detection of DNA by beacon-assisted detection amplification.

Ashley Connolly, Matt Trau

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

Abstract

(Figure Presented) Not bad at all: A simple biological circuit composed of two integrated molecular switches was developed for the detection and amplification of a specific nucleic acid in a biological extract. The nucleic acid is recognized by a molecular beacon, then a DNA polymerase and nicking endonuclease are used to rapidly amplify the signal for sensitive detection of the nucleic acid.

Original language	English
Pages (from-to)	2720-2723
Number of pages	4
Journal	Angewandte Chemie-International Edition
Volume	49
Issue number	15
DOIs	https://doi.org/10.1002/anie.200906992
Publication status	Published - 1 Apr 2010

Keywords

Biosensors
DNA detection
DNA nanomachines
Molecular devices
Nanobiotechnology

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10.1002/anie.200906992

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abstract = "(Figure Presented) Not bad at all: A simple biological circuit composed of two integrated molecular switches was developed for the detection and amplification of a specific nucleic acid in a biological extract. The nucleic acid is recognized by a molecular beacon, then a DNA polymerase and nicking endonuclease are used to rapidly amplify the signal for sensitive detection of the nucleic acid.",

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AB - (Figure Presented) Not bad at all: A simple biological circuit composed of two integrated molecular switches was developed for the detection and amplification of a specific nucleic acid in a biological extract. The nucleic acid is recognized by a molecular beacon, then a DNA polymerase and nicking endonuclease are used to rapidly amplify the signal for sensitive detection of the nucleic acid.

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KW - DNA nanomachines

KW - Molecular devices

KW - Nanobiotechnology

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Isothermal detection of DNA by beacon-assisted detection amplification.

Abstract

Keywords

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