Isothermal detection of DNA by beacon-assisted detection amplification.

Ashley Connolly, Matt Trau

    Research output: Contribution to journalArticlepeer-review

    127 Citations (Scopus)

    Abstract

    (Figure Presented) Not bad at all: A simple biological circuit composed of two integrated molecular switches was developed for the detection and amplification of a specific nucleic acid in a biological extract. The nucleic acid is recognized by a molecular beacon, then a DNA polymerase and nicking endonuclease are used to rapidly amplify the signal for sensitive detection of the nucleic acid.

    Original languageEnglish
    Pages (from-to)2720-2723
    Number of pages4
    JournalAngewandte Chemie-International Edition
    Volume49
    Issue number15
    DOIs
    Publication statusPublished - 1 Apr 2010

    Keywords

    • Biosensors
    • DNA detection
    • DNA nanomachines
    • Molecular devices
    • Nanobiotechnology

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