It is time to further expand research in tailoring self-management of COPD exacerbations!

Anke Lenferink, Job van der Palen, Paul D.L.P.M. van der Valk, Morton G. Burt, Peter A. Frith, Marjolein G.J. Brusse-Keizer, Tanja W. Effing

Research output: Contribution to journalLetterpeer-review


We are grateful to the editors of the European Respiratory Journal for the opportunity to respond to the letter to the editor by S. Ramakrishnan and M. Bafadhel, whom we thank for their thoughtful remarks about our COPE-III self-management trial [1]. Whereas our study did not show a significant difference in the number of COPD exacerbation days per year, the results showed that exacerbation action plans for COPD patients with comorbidities, embedded in a patient-tailored self-management intervention, reduced the duration of COPD exacerbations and the risk of respiratory-related hospitalisation, without increasing all-cause mortality [1]. In our study, we did not phenotype COPD exacerbations by airway eosinophilic inflammation prior to randomisation.
Original languageEnglish
Article number1902225
Pages (from-to)2-4
Number of pages3
JournalEuropean Respiratory Journal
Issue number1
Publication statusPublished - 1 Jan 2020


  • Self-Management
  • COPD Exacerbations
  • Research


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