Kainic acid injection in NTS evokes hypertension and c-fos expression in spinal cord

Jane Minson, Vimal Kapoor, Ida Llewellyn Smith, Paul Pilowsky, John Chalmers

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retro-gradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.

    Original languageEnglish
    Pages (from-to)437-440
    Number of pages4
    JournalNeuroreport
    Volume3
    Issue number5
    DOIs
    Publication statusPublished - May 1992

    Keywords

    • Blood pressure
    • Fos-immunoreactivity
    • Intermediolateral cell column
    • Retrograde tracing
    • Sympathetic preganglionic neuron
    • Ventrolateral medulla

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