Kainic acid injection in NTS evokes hypertension and c-fos expression in spinal cord

Jane Minson; Vimal Kapoor; Ida Llewellyn Smith; Paul Pilowsky; John Chalmers

doi:10.1097/00001756-199205000-00015

Kainic acid injection in NTS evokes hypertension and c-fos expression in spinal cord

Jane Minson, Vimal Kapoor, Ida Llewellyn Smith, Paul Pilowsky, John Chalmers

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retro-gradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.

Original language	English
Pages (from-to)	437-440
Number of pages	4
Journal	Neuroreport
Volume	3
Issue number	5
DOIs	https://doi.org/10.1097/00001756-199205000-00015
Publication status	Published - May 1992

Keywords

Blood pressure
Fos-immunoreactivity
Intermediolateral cell column
Retrograde tracing
Sympathetic preganglionic neuron
Ventrolateral medulla

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title = "Kainic acid injection in NTS evokes hypertension and c-fos expression in spinal cord",

abstract = "Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retro-gradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.",

keywords = "Blood pressure, Fos-immunoreactivity, Intermediolateral cell column, Retrograde tracing, Sympathetic preganglionic neuron, Ventrolateral medulla",

author = "Jane Minson and Vimal Kapoor and Smith, {Ida Llewellyn} and Paul Pilowsky and John Chalmers",

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AU - Minson, Jane

AU - Kapoor, Vimal

AU - Smith, Ida Llewellyn

AU - Pilowsky, Paul

AU - Chalmers, John

PY - 1992/5

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N2 - Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retro-gradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.

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KW - Blood pressure

KW - Fos-immunoreactivity

KW - Intermediolateral cell column

KW - Retrograde tracing

KW - Sympathetic preganglionic neuron

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Kainic acid injection in NTS evokes hypertension and c-fos expression in spinal cord

Abstract

Keywords

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