Knockout of p75NTR ligand- binding domain decreases the hyperphosphorylation of Tau in P301L mice model

Noralyn Manucat-Tan; Larisa Bobrovskaya; Yan Jiang Wang; Xin Fu Zhou

doi:10.1016/j.jalz.2016.06.1461

Knockout of p75NTR ligand- binding domain decreases the hyperphosphorylation of Tau in P301L mice model

Noralyn Manucat-Tan, Larisa Bobrovskaya, Yan Jiang Wang, Xin Fu Zhou

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

p75NTR, a neurotrophin receptor is found to be involved in amyloid beta pathology and tau hyperphosphorylation in patients and animal model with Alzheimer’s disease (AD). However, the mechanism on how p75NTR is involved in tau phosphorylation remains unclear. The extracellular domain (ECD) of p75NTR was found to block amyloid beta toxicity and attenuate tau hyperphosphorylation. The ligand-binding region in the extracellular domain of p75NTR was knocked out in pR5 (P301L) mice model to determine its function in tau hyperphosphorylation.

Original language	English
Pages (from-to)	P769
Number of pages	1
Journal	Alzheimer's & Dementia
Volume	12
Issue number	7S, Part 15
DOIs	https://doi.org/10.1016/j.jalz.2016.06.1461
Publication status	Published - Jul 2016
Externally published	Yes
Event	Alzheimer’s Association International Conference 2016 - Toronto, Canada Duration: 22 Jul 2016 → 28 Jul 2016

Keywords

p75NTR
ligand binding
Tau hyperphophorylation
P301L tau transgenic mouse
Extracellular

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title = "Knockout of p75NTR ligand- binding domain decreases the hyperphosphorylation of Tau in P301L mice model",

abstract = "p75NTR, a neurotrophin receptor is found to be involved in amyloid beta pathology and tau hyperphosphorylation in patients and animal model with Alzheimer{\textquoteright}s disease (AD). However, the mechanism on how p75NTR is involved in tau phosphorylation remains unclear. The extracellular domain (ECD) of p75NTR was found to block amyloid beta toxicity and attenuate tau hyperphosphorylation. The ligand-binding region in the extracellular domain of p75NTR was knocked out in pR5 (P301L) mice model to determine its function in tau hyperphosphorylation.",

keywords = "p75NTR, ligand binding, Tau hyperphophorylation, P301L tau transgenic mouse, Extracellular",

author = "Noralyn Manucat-Tan and Larisa Bobrovskaya and Wang, {Yan Jiang} and Zhou, {Xin Fu}",

year = "2016",

month = jul,

doi = "10.1016/j.jalz.2016.06.1461",

language = "English",

volume = "12",

pages = "P769",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "7S, Part 15",

note = "Alzheimer{\textquoteright}s Association International Conference 2016 ; Conference date: 22-07-2016 Through 28-07-2016",

}

TY - JOUR

T1 - Knockout of p75NTR ligand- binding domain decreases the hyperphosphorylation of Tau in P301L mice model

AU - Manucat-Tan, Noralyn

AU - Bobrovskaya, Larisa

AU - Wang, Yan Jiang

AU - Zhou, Xin Fu

PY - 2016/7

Y1 - 2016/7

N2 - p75NTR, a neurotrophin receptor is found to be involved in amyloid beta pathology and tau hyperphosphorylation in patients and animal model with Alzheimer’s disease (AD). However, the mechanism on how p75NTR is involved in tau phosphorylation remains unclear. The extracellular domain (ECD) of p75NTR was found to block amyloid beta toxicity and attenuate tau hyperphosphorylation. The ligand-binding region in the extracellular domain of p75NTR was knocked out in pR5 (P301L) mice model to determine its function in tau hyperphosphorylation.

AB - p75NTR, a neurotrophin receptor is found to be involved in amyloid beta pathology and tau hyperphosphorylation in patients and animal model with Alzheimer’s disease (AD). However, the mechanism on how p75NTR is involved in tau phosphorylation remains unclear. The extracellular domain (ECD) of p75NTR was found to block amyloid beta toxicity and attenuate tau hyperphosphorylation. The ligand-binding region in the extracellular domain of p75NTR was knocked out in pR5 (P301L) mice model to determine its function in tau hyperphosphorylation.

KW - p75NTR

KW - ligand binding

KW - Tau hyperphophorylation

KW - P301L tau transgenic mouse

KW - Extracellular

U2 - 10.1016/j.jalz.2016.06.1461

DO - 10.1016/j.jalz.2016.06.1461

M3 - Meeting Abstract

SN - 1552-5260

VL - 12

SP - P769

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 7S, Part 15

T2 - Alzheimer’s Association International Conference 2016

Y2 - 22 July 2016 through 28 July 2016

ER -

Knockout of p75NTR ligand- binding domain decreases the hyperphosphorylation of Tau in P301L mice model

Abstract

Keywords

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