Lacidipine, hydrochlorothiazide and their combination in systolic hypertension in the elderly

Lindon M.H. Wing, Leonard F. Arnolda, Paula J. Harvey, Jane Upton, Danielle Molloy, Alexandra J.C. Bune, John P. Chalmers

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12 Citations (Scopus)


To compare with placebo the efficacies of once-daily administrations of lacidipine and hydrochlorothiazide separately and in combination to elderly patients with systolic hypertension. Nineteen elderly subjects (five men and 14 women, median age 71 years, range 62-79 years) participated in the study, which had a randomized double-blind crossover design. For each subject there were four treatment phases, each of duration 4 weeks. The initial treatments in each phase were 2 mg lacidipine once a day and 25 mg hydrochlorothiazide once a day, separately and in combination, and placebo. Doses of each agent could be doubled after 2 weeks in each phase if the patient's goal systolic blood pressure had not been achieved. The numbers of subjects administered the higher dose of each treatment were 13 for placebo, 14 for lacidipine, 11 for hydrochlorothiazide and eight for lacidipine plus hydrochlorothiazide.

Original languageEnglish
Pages (from-to)1503-1510
Number of pages8
JournalJournal of Hypertension
Issue number12
Publication statusPublished - Dec 1997
Externally publishedYes


  • Calcium channel antagonists
  • Diuretics
  • Elderly
  • Hydrochlorothiazide
  • Lacidipine
  • Systolic hypertension


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