Lack of correlation between in vitro and in vivo effects of low density lipoprotein on the inflammatory activity of monosodium urate crystals

T. P. Gordon, P. Clifton, M. J. James, P. J. Roberts-Thomson

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2 Citations (Scopus)

Abstract

The effect of coating monosodium urate crystals (MSU) with low density lipoprotein (LDL), postulated previously as a major regulator of gouty inflammation, was studied in a neutrophil chemiluminesce (CL) assay and an air pouch model of inflammation induced by MSU. LDL crystalline coating abrogated the neutrophil CL response but, in contrast, had no inhibitory effect on leucocyte accumulation, levels of the prostaglandin (PG) metabolite 6-keto-PGF(1α), and exudation of plasma proteins in the in vivo model. This latter observation raises doubts about the postulated physiological role of LDL in terminating the acute gouty attack.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume45
Issue number8
DOIs
Publication statusPublished - 1986
Externally publishedYes

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