Lack Of Increased Differentiation Of Leukemic Cells In Response To Colony-Stimulating Factor 1

Alec Morley, David Higgs

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cells from 11 patients with acute myeloid or myelomonocytic leukemia were exposed to high and low concentrations of colony-stimulating factor by culturing them on basal layers that did or did not contain normal leukocytes, by culturing at high or low cell concentrations, and by adding colony-stimulating factor to the cultures. The degree of differentiation was assessed morphologically. There was no significant difference in the degree of differentiation produced by these experimental manipulations, suggesting that the colony-stimulating factor has relatively little influence on leukemic cell differentiation.

Original languageEnglish
Pages (from-to)2307-2310
Number of pages4
JournalCancer Research
Volume34
Issue number9
Publication statusPublished - Sep 1974
Externally publishedYes

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