Laminar distribution of fos/calcium-binding protein and fos/neurofilament protein-labeled neurons in rat motor and sensory cortex after picrotoxin-induced seizures

Jennifer J. Hiscock, L. MacKenzie, J. O. Willoughby

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Cerebrocortical Fos induction after picrotoxin-induced seizure occurs in spiny neurons and, to a lesser extent, in neurons defined by calcium-binding protein immunoreactivity. In motor and sensory cortex of rats we have defined the laminar distribution of Fos expression in these neurons. Initially we defined the laminar distributions of parvalbumin-, calbindin-D 28K-, and calretinin-immunoreactive aspiny neurons; these were unique for each class and similar across cortical regions. Spiny cells defined by SM132 immunoreactivity were distributed with two peaks and there were differences between cortical regions. Parvalbumin-immunoreactive neurons exhibited peak numbers where numbers of SMI32-immunoreactive neurons were low. The distribution of Fos induction across laminae matched that of its class for calbindin-D 28K and calretinin neurons; however, Fos induction was less in infragranular compared with supragranular for parvalbumin in motor cortex and SMI32 containing neurons in both cortices. In both these latter cell classes Fos induction was inversely correlated with neuronal size. It is suggested that cell size within some cell classes is one factor that determines the extent of Fos induction within that class following seizures.

    Original languageEnglish
    Pages (from-to)373-383
    Number of pages11
    JournalExperimental Neurology
    Volume149
    Issue number2
    DOIs
    Publication statusPublished - Feb 1998

    Keywords

    • Calbindin-D 28K
    • Calretinin
    • Fos induction
    • Immunohistochemistry
    • Neuron size
    • Parvalbumin
    • Single seizures

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