TY - JOUR
T1 - LCPUFAs as Conditionally Essential Nutrients for Very Low Birth Weight and Low Birth Weight Infants. Metabolic, Functional, and Clinical Outcomes-How Much is Enough?
AU - Makrides, Maria
AU - Uauy, Ricardo
PY - 2014/6
Y1 - 2014/6
N2 - Preterm infants are denied the rapid accumulation of docosahexaenoic acid (DHA) occurring during the third trimester in utero. The potential benefit of long-chain polyunsaturated fatty acids (LCPUFAs) has generated interest over the last 3 decades. Early intervention trials assessed the effects of supplementing infant formulas lacking DHA with concentrations equivalent to LCPUFA in milk of women from Westernized societies, leading to the inclusion of LCPUFA by the year 2000. Recently attention has been on determining the optimal dose of DHA and on whether there is in advantage in matching the higher doses of late pregnancy.
AB - Preterm infants are denied the rapid accumulation of docosahexaenoic acid (DHA) occurring during the third trimester in utero. The potential benefit of long-chain polyunsaturated fatty acids (LCPUFAs) has generated interest over the last 3 decades. Early intervention trials assessed the effects of supplementing infant formulas lacking DHA with concentrations equivalent to LCPUFA in milk of women from Westernized societies, leading to the inclusion of LCPUFA by the year 2000. Recently attention has been on determining the optimal dose of DHA and on whether there is in advantage in matching the higher doses of late pregnancy.
KW - Development
KW - LCPUFA
KW - Low birth weight infants
KW - Preterm
KW - Randomized controlled trials
KW - Very low birth weight infants
UR - http://www.scopus.com/inward/record.url?scp=84901587059&partnerID=8YFLogxK
U2 - 10.1016/j.clp.2014.02.012
DO - 10.1016/j.clp.2014.02.012
M3 - Article
VL - 41
SP - 451
EP - 461
JO - CLINICS IN PERINATOLOGY
JF - CLINICS IN PERINATOLOGY
SN - 0095-5108
IS - 2
ER -