Leptin Mediates the Increase in Blood Pressure Associated with Obesity

Stephanie Simonds, Jack Pryor, Eric Ravussin, Frank Greenway, Ralph Dileone, Andrew Allen, Jaspreet Bassi, Joel Elmquist, Julia Keogh, Elana Henning, Martin Myers Jr, Julio Licinio, Russell Brown, Pablo Enriori, Stephen O'Rahilly, Scott Sternson, Kevin Grove, David Spanswick, Sadaf Farooqi, Michael Cowley

    Research output: Contribution to journalArticle

    172 Citations (Scopus)

    Abstract

    Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species.

    Original languageEnglish
    Pages (from-to)1404-1416
    Number of pages13
    JournalCell
    Volume159
    Issue number6
    DOIs
    Publication statusPublished - 2014

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