Leptina: Mecanismos moleculares, efeitos próinflamatórios sistêmicos e implicações clínicas

Gilberto Paz-Filho, Claudio Mastronardi, Carina Franco, Kevin Wang, Ma-Li Wong, Julio Licinio

    Research output: Contribution to journalReview articlepeer-review

    136 Citations (Scopus)


    Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders.

    Original languagePortuguese
    Pages (from-to)597-607
    Number of pages11
    JournalArquivos Brasileiros de Endocrinologia e Metabologia
    Issue number9
    Publication statusPublished - Dec 2012


    • Cytokines
    • Immunity
    • Inflammation
    • Leptin

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