LESIONS OF THE VENTROLATERAL MEDULLA IN NORMAL AND VASOPRESSIN‐DEFICIENT (BRATTLEBORO) RATS

J. B. Minson; J. P. Chalmers

doi:10.1111/j.1440-1681.1984.tb00293.x

LESIONS OF THE VENTROLATERAL MEDULLA IN NORMAL AND VASOPRESSIN‐DEFICIENT (BRATTLEBORO) RATS

J. B. Minson, J. P. Chalmers

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1. The cardiovascular response to electrolytic lesions of the A1 noradrenaline cell group (A1 lesion) were studied in the rat. 2. A1 lesions in normal rats cause acute hypertension and bradycardia and elevate plasma arginine‐vasopressin (AVP), as previously described in the rabbit. 3. After A1 lesions in vasopressin deficient rats the hypertension is not reduced compared to that seen in normal rats, but the bradycardia is attenuated. 4. AVP makes a greater contribution to the bradycardia than to the hypertension after A1 lesions.

Original language	English
Pages (from-to)	427-430
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1681.1984.tb00293.x
Publication status	Published - Aug 1984

Keywords

A1 noradrenergic neurons
arterial pressure
heart rate
plasma vasopressin

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AU - Chalmers, J. P.

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N2 - 1. The cardiovascular response to electrolytic lesions of the A1 noradrenaline cell group (A1 lesion) were studied in the rat. 2. A1 lesions in normal rats cause acute hypertension and bradycardia and elevate plasma arginine‐vasopressin (AVP), as previously described in the rabbit. 3. After A1 lesions in vasopressin deficient rats the hypertension is not reduced compared to that seen in normal rats, but the bradycardia is attenuated. 4. AVP makes a greater contribution to the bradycardia than to the hypertension after A1 lesions.

AB - 1. The cardiovascular response to electrolytic lesions of the A1 noradrenaline cell group (A1 lesion) were studied in the rat. 2. A1 lesions in normal rats cause acute hypertension and bradycardia and elevate plasma arginine‐vasopressin (AVP), as previously described in the rabbit. 3. After A1 lesions in vasopressin deficient rats the hypertension is not reduced compared to that seen in normal rats, but the bradycardia is attenuated. 4. AVP makes a greater contribution to the bradycardia than to the hypertension after A1 lesions.

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KW - arterial pressure

KW - heart rate

KW - plasma vasopressin

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JO - Clinical and Experimental Pharmacology and Physiology

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ER -

LESIONS OF THE VENTROLATERAL MEDULLA IN NORMAL AND VASOPRESSIN‐DEFICIENT (BRATTLEBORO) RATS

Abstract

Keywords

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