Lesson of the month 2: An unusual cause of depression in an older man: Cushing's syndrome resulting from metastatic small cell cancer of the prostate

Paul Kleinig, Patrick Russell

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression.

Original languageEnglish
Pages (from-to)432-434
Number of pages3
JournalClinical Medicine, Journal of the Royal College of Physicians of London
Volume18
Issue number5
DOIs
Publication statusPublished - 1 Oct 2018
Externally publishedYes

Keywords

  • ACTH syndrome
  • Autopsy
  • Carcinoma
  • Clinicopathological conference
  • Depression
  • Ectopic
  • Prostatic neoplasms
  • Small cell

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