Light-activated chimeric GPCRs: limitations and opportunities

Alexandra Madelaine Tichy, Elliot J. Gerrard, Patrick M. Sexton, Harald Janovjak

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Light-activated chimeric GPCRs, termed OptoXRs, can elicit cell signalling responses with the high spatial and temporal precision of light. In recent years, an expanding OptoXR toolkit has been applied to, for example, dissect neural circuits in awake rodents, guide cell migration during vertebrate development and even restore visual responses in a rodent model of blindness. OptoXRs have been further developed through incorporation of highly sensitive photoreceptor domains and a plethora of signalling modules. The availability of new high-resolution structures of GPCRs and a deeper understanding of GPCR function allows critically revisitation of the design of OptoXRs. Next-generation OptoXRs will build on advances in structural biology, receptor function and photoreceptor diversity to manipulate GPCR signalling with unprecedented accuracy and precision.

Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalCurrent Opinion in Structural Biology
Publication statusPublished - Aug 2019
Externally publishedYes


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