TY - JOUR
T1 - Light-adapted electroretinogram differences in Autism Spectrum Disorder
AU - Constable, Paul
AU - Ritvo, Edward
AU - Ritvo, Ariella
AU - Lee, Irene
AU - McNair, Morgan
AU - Stahl, Dylan
AU - Sowden, Jane
AU - Quinn, Stephen
AU - Skuse, David
AU - Thompson, Dorothy
AU - McPartland, James
PY - 2020/2/7
Y1 - 2020/2/7
N2 - Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.
AB - Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.
KW - autism spectrum disorder
KW - Electroretinogram
KW - b-wave
KW - Autism spectrum disorder
UR - http://www.scopus.com/inward/record.url?scp=85079159132&partnerID=8YFLogxK
U2 - 10.1007/s10803-020-04396-5
DO - 10.1007/s10803-020-04396-5
M3 - Article
VL - 50
SP - 2874
EP - 2885
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 8
ER -