Research output per year
Research output per year
Paul Constable, Edward Ritvo, Ariella Ritvo, Irene Lee, Morgan McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David Skuse, Dorothy Thompson, James McPartland
Research output: Contribution to journal › Article › peer-review
Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.
Original language | English |
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Pages (from-to) | 2874-2885 |
Number of pages | 12 |
Journal | Journal of Autism and Developmental Disorders |
Volume | 50 |
Issue number | 8 |
DOIs | |
Publication status | Published - 7 Feb 2020 |
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Research output: Contribution to journal › Article › peer-review