Light-adapted electroretinogram differences in Autism Spectrum Disorder

Paul Constable, Edward Ritvo, Ariella Ritvo, Irene Lee, Morgan McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David Skuse, Dorothy Thompson, James McPartland

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21 Citations (Scopus)


Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

Original languageEnglish
Pages (from-to)2874-2885
Number of pages12
JournalJournal of Autism and Developmental Disorders
Issue number8
Publication statusPublished - 7 Feb 2020


  • autism spectrum disorder
  • Electroretinogram
  • b-wave
  • Autism spectrum disorder


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