Light-adapted electroretinogram differences in Autism Spectrum Disorder

Paul Constable, Edward Ritvo, Ariella Ritvo, Irene Lee, Morgan McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David Skuse, Dorothy Thompson, James McPartland

Research output: Contribution to journalArticle

Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

Original languageEnglish
Pages (from-to)2874-2885
Number of pages12
JournalJournal of Autism and Developmental Disorders
Volume50
Issue number8
DOIs
Publication statusPublished - 7 Feb 2020

Keywords

  • autism spectrum disorder
  • Electroretinogram
  • b-wave
  • Autism spectrum disorder

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    Constable, P., Ritvo, E., Ritvo, A., Lee, I., McNair, M., Stahl, D., Sowden, J., Quinn, S., Skuse, D., Thompson, D., & McPartland, J. (2020). Light-adapted electroretinogram differences in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 50(8), 2874-2885. https://doi.org/10.1007/s10803-020-04396-5