Light-adapted electroretinogram differences in Autism Spectrum Disorder

Paul Constable; Edward Ritvo; Ariella Ritvo; Irene Lee; Morgan McNair; Dylan Stahl; Jane Sowden; Stephen Quinn; David Skuse; Dorothy Thompson; James McPartland

doi:10.1007/s10803-020-04396-5

Light-adapted electroretinogram differences in Autism Spectrum Disorder

Paul Constable, Edward Ritvo, Ariella Ritvo, Irene Lee, Morgan McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David Skuse, Dorothy Thompson, James McPartland

College of Nursing and Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m⁻² white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

Original language	English
Pages (from-to)	2874-2885
Number of pages	12
Journal	Journal of Autism and Developmental Disorders
Volume	50
Issue number	8
DOIs	https://doi.org/10.1007/s10803-020-04396-5
Publication status	Published - 7 Feb 2020

Keywords

autism spectrum disorder
Electroretinogram
b-wave
Autism spectrum disorder

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title = "Light-adapted electroretinogram differences in Autism Spectrum Disorder",

abstract = "Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.",

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author = "Paul Constable and Edward Ritvo and Ariella Ritvo and Irene Lee and Morgan McNair and Dylan Stahl and Jane Sowden and Stephen Quinn and David Skuse and Dorothy Thompson and James McPartland",

year = "2020",

month = feb,

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doi = "10.1007/s10803-020-04396-5",

language = "English",

volume = "50",

pages = "2874--2885",

journal = "Journal of Autism and Developmental Disorders",

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Light-adapted electroretinogram differences in Autism Spectrum Disorder. / Constable, Paul; Ritvo, Edward; Ritvo, Ariella; Lee, Irene; McNair, Morgan; Stahl, Dylan; Sowden, Jane; Quinn, Stephen; Skuse, David; Thompson, Dorothy; McPartland, James.

In: Journal of Autism and Developmental Disorders, Vol. 50, No. 8, 07.02.2020, p. 2874-2885.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Light-adapted electroretinogram differences in Autism Spectrum Disorder

AU - Constable, Paul

AU - Ritvo, Edward

AU - Ritvo, Ariella

AU - Lee, Irene

AU - McNair, Morgan

AU - Stahl, Dylan

AU - Sowden, Jane

AU - Quinn, Stephen

AU - Skuse, David

AU - Thompson, Dorothy

AU - McPartland, James

PY - 2020/2/7

Y1 - 2020/2/7

N2 - Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

AB - Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

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