Linear and branched polyacrylates as a delivery platform for peptide-based vaccines

Saranya Chandrudu, Stacey Bartlett, Zeinab G. Khalil, Zhongfan Jia, Waleed M. Hussein, Robert J. Capon, Michael R. Batzloff, Michael F. Good, Michael J. Monteiro, Mariusz Skwarczynski, Istvan Toth

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Aim: Peptide-based vaccines are designed to carry the minimum required antigen to trigger the desired immune responses; however, they are usually poorly immunogenic and require appropriate delivery system. Results: Peptides, B-cell epitope (J14) derived from group A streptococcus M-protein and universal T-helper (PADRE) epitope, were conjugated to a variety of linear and branched polyacrylates. All produced conjugates formed submicron-sized particles and induced a high level of IgG titres in mice after subcutaneous immunization. These polymer-peptide conjugates demonstrated high opsonization capacity against group A streptococcus clinical isolates. Conclusion: We have successfully demonstrated that submicron-sized polymer-peptide conjugates were capable of inducing strong humoral immune responses after single immunization.

Original languageEnglish
Pages (from-to)601-609
Number of pages9
JournalTherapeutic Delivery
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 2016
Externally publishedYes

Keywords

  • clinical isolates
  • group A streptococcus
  • nanoparticles
  • opsonization
  • peptide vaccine
  • polyacrylates
  • polymer-peptide conjugate
  • single immunization
  • vaccine delivery

Fingerprint Dive into the research topics of 'Linear and branched polyacrylates as a delivery platform for peptide-based vaccines'. Together they form a unique fingerprint.

Cite this