Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus)

Marija Knez, Elad Tako, Raymond Glahn, Nikolai Kolba, Emma de Courcy-Ireland, James Stangoulis

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The amount of Zn absorbed from Zn-biofortified wheat material has been determined using an in vivo model of Zn absorption. The erythrocyte linoleic:dihomo -γ-linolenic acid (LA:DGLA) ratio was used as a biomarker of Zn status. Two groups of chickens (n = 15) were fed different diets: a high-Zn (46.5 μg Zn g-1) and a low-Zn wheat-based diet (32.8 μg Zn g-1). Dietary Zn intakes, body weight, serum Zn, and the erythrocyte fatty acid profile were measured, and tissues were taken for gene expression analysis. Serum Zn concentrations were greater in the high Zn group (p < 0.05). Duodenal mRNA expression of various Zn transporters demonstrated expression upregulation in the birds fed a low Zn diet (n = 15, p < 0.05). The LA:DGLA ratio was higher in the birds fed the low Zn diet (p < 0.05). The higher amount of Zn in the biofortified wheat resulted in a greater Zn uptake.

Original languageEnglish
Pages (from-to)1394-1400
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume66
Issue number6
DOIs
Publication statusPublished - 14 Feb 2018

Keywords

  • zinc
  • Zn biofortification
  • wheat
  • Zn transporters
  • LA:DGLA
  • Zn biomarker

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