Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study

Stephanie L. Harrison; Deirdre A. Lane; Maciej Banach; Mirosław Mastej; Sławomir Kasperczyk; J. J. Jóźwiak; Gregory Y.H. Lip; LIPIDOGRAM2015 Investigators

doi:10.1016/j.atherosclerosis.2020.08.026

Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study

Stephanie L. Harrison, Deirdre A. Lane, Maciej Banach, Mirosław Mastej, Sławomir Kasperczyk, J. J. Jóźwiak, Gregory Y.H. Lip, LIPIDOGRAM2015 Investigators

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background and aims: An inverse relationship between lipid levels and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. Methods: Multivariate Poisson regression models were used to estimate prevalence ratios (PRs) for AF by lipid levels. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), non-HDL-C and LDL-C/HDL-C ratios were grouped into quartiles. Results: Of the 13,724 participants, 5.2% (n = 708) had AF. People with AF were older with more comorbidities, but lower lipid levels (all p < 0.05). The prevalence of AF was inversely associated with LDL-C (Adjusted PR (95% Confidence Interval) highest versus lowest quartile: 0.60 (0.48, 0.75)), TC (0.61 (0.49, 0.75)) and non-HDL-C (0.63 (0.51, 0.78)). The prevalence of AF was inversely associated with HDL-C (0.58 (0.46, 0.74)), but this was not statistically significant for people aged 75 years and older. For the LDL-C/HDL-C ratio, the prevalence of AF was only inversely associated with higher levels for people aged 75 years and older (0.75 (0.61, 0.94)). There was no statistically significant difference in prevalence of AF by TG levels. Conclusions: The results suggest an inverse relationship between lipid levels and AF. The inverse association between higher HDL-C and AF was only significant for people aged <75 years, whereas the inverse association between higher LDL-C/HDL-C ratio and AF was only significant for people aged 75 years and older.

Original language	English
Pages (from-to)	16-22
Number of pages	7
Journal	Atherosclerosis
Volume	312
DOIs	https://doi.org/10.1016/j.atherosclerosis.2020.08.026
Publication status	Published - Nov 2020
Externally published	Yes

Keywords

Age
Atrial fibrillation
Cholesterol
Epidemiology
Lipids
Prevalence

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10.1016/j.atherosclerosis.2020.08.026Licence: In Copyright

Cite this

@article{22a117035e524e16abb54db39b977f58,

title = "Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study",

abstract = "Background and aims: An inverse relationship between lipid levels and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. Methods: Multivariate Poisson regression models were used to estimate prevalence ratios (PRs) for AF by lipid levels. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), non-HDL-C and LDL-C/HDL-C ratios were grouped into quartiles. Results: Of the 13,724 participants, 5.2% (n = 708) had AF. People with AF were older with more comorbidities, but lower lipid levels (all p < 0.05). The prevalence of AF was inversely associated with LDL-C (Adjusted PR (95% Confidence Interval) highest versus lowest quartile: 0.60 (0.48, 0.75)), TC (0.61 (0.49, 0.75)) and non-HDL-C (0.63 (0.51, 0.78)). The prevalence of AF was inversely associated with HDL-C (0.58 (0.46, 0.74)), but this was not statistically significant for people aged 75 years and older. For the LDL-C/HDL-C ratio, the prevalence of AF was only inversely associated with higher levels for people aged 75 years and older (0.75 (0.61, 0.94)). There was no statistically significant difference in prevalence of AF by TG levels. Conclusions: The results suggest an inverse relationship between lipid levels and AF. The inverse association between higher HDL-C and AF was only significant for people aged <75 years, whereas the inverse association between higher LDL-C/HDL-C ratio and AF was only significant for people aged 75 years and older.",

keywords = "Age, Atrial fibrillation, Cholesterol, Epidemiology, Lipids, Prevalence",

author = "Harrison, {Stephanie L.} and Lane, {Deirdre A.} and Maciej Banach and Miros{\l}aw Mastej and S{\l}awomir Kasperczyk and J{\'o}{\'z}wiak, {J. J.} and Lip, {Gregory Y.H.} and {LIPIDOGRAM2015 Investigators} and B. Al-Shaer and W. Andrusewicz and M. Andrzejczuk-Rosa and E. Anusz-Gaszewska and A. Bagi{\'n}ska and P. Balawajder and G. Ba{\'n}ka and E. Bara{\'n}ska-Skubisz and {Barbara Przyczyna}, B. and S. Bartkowiak and J. Bartodziej and M. Bartosiewicz and M. Basa{\l}yga and A. Batyra and A. B{\c a}k and M. Bednarz and K. Bejnar and W. Bernacki and M. Betiuk-Kwiatkowska and S. Biegaj and M. Bie{\'n} and W. Bilski and M. Bi{\l}ogan and G. Biruta-Paw{\l}owska and A. Biskup and B. B{\l}aszczyk and H. B{\l}aszczyk and T. B{\l}o{\'n}ska-Jankowska and B. Bogacka-Gancarczyk and M. Bojanowska and E. Bonda and J. Borowik-Skwarek and J. Borowska and J. Bruckner and J. Brzostek and M. Brzuchacz and M. Budzy{\'n}ska and I. Bulzacka-Fugiel and J. Bulzak and K. Bunikowski and A. Cebulska and T. Celka and E. Cempel-Nowak and W. Chechli{\'n}ski and A. Chludzi{\'n}ska and D. Chmiel and M. Chmielewska and M. Cichy and A. Ciemi{\c e}ga and A. Ciepluch and I. Cieszy{\'n}ska and B. Czajka and B. Czapla and M. Czerner and B. Czerwi{\'n}ska and W. Czuryszkiewicz and E. Daleka and Z. Dawid and M. D{\c a}browska and R. D{\c a}browska and D. D{\c a}browski and M. D{\c a}browski and K. Demczyszyn and A. D{\c e}bowska-Serwi{\'n}ska and J. Dmochowski and J. Dobrzecka-Kiwior and E. Dolanowska and H. Dolanowski and P. Do{\l}ek and M. Domaga{\l}a and H. Doma{\'n}ski and A. Doszel and D. Duda and M. Dudkowska and B. Dudziuk and P. Dybciak and M. Dymanowski and L. Dziadzio-Bolek and M. Eicke and H. El-Hassan and A. Eremus and M. F{\c a}ferek-Muller and E. Figura-Roguska and I. Fija{\l}kowska-Kaczmarek and M. Flis and T. Florczak and M. Florczuk and E. Foryszewska-Witan and W. Frydrych and A. Fugiel and E. Futyma and A. Gaca-Jaroszewicz and I. Gajdamowicz and K. Ganczarski and A. Gatnar and M. Gers and A. G{\l}owacki and K. G{\l}{\'o}d and J. Godula and J. Go{\l}{\c a}b and M. Go{\l}{\c e}biewski and E. Goszczy{\'n}ska and K. Go{\'s}cicka and A. G{\'o}rna-Hajduga and E. G{\'o}rny and T. Grabowska and R. Grabowski and A. Graczyk-Duda and A. Gromow and A. Grudewicz and J. Gruszecka and A. Gruszka and J. Grybo{\'s} and J. Grzebyk and A. Grzechowiak and D. Grzesiak and T. Grze{\'s}kowiak and A. Gu{\'z}la and G. Hachu{\l}a and B. Hawel and H. Hiltawska and E. Honkowicz and J. Ignatowicz and K. Imielski and A. Iwaniura and A. Jagie{\l}a-Szymala and M. Jal{\'c}-Sowa{\l}a and A. Janczylik and E. Janisz and M. Janiszek and K. Jankiewicz-Ziobro and K. Januszewska and A. Jaremek and A. Jaros-Urbaniak and J. Jarosz and P. Jarosz and W. Jasi{\'n}ski and M. Jezierska-Wasilewska and T. J{\c e}draszewski and A. J{\c e}drzejowska and R. J{\'o}zefowicz and J{\'o}{\'z}wiak, {J. J.} and K. Ju{\'z}win and E. Kacprzak and J. Kaczmarek-Szewczyk and M. Kaczmarzyk and R. Kandziora and C. Kaniewski and L. Karolak-Brandt and S. Kasperczyk and E. Kasperek-Dyl{\c a}g and I. Kedziora and A. K{\c e}pa and J. Kici{\'n}ski and J. Kielak-Al-Hosam and Kie{\l}czawa and P. Kilimowicz and K. Kitli{\'n}ski and T. Kiwka and U. Klein and L. Klichowicz and A. Klimowicz and B. Klonowski and B. Kmolek and E. Koby{\l}ko-Klepacka and A. Koco{\'n} and A. Kolenda and E. Kollek and M. Kope{\'c} and B. Koper-Kozikowska and J. Koralewska and M. Korczy{\'n}ska and Korzeniewski, {M. T.} and A. Kosk and K. Kotarski and E. Kowalczyk and M. Kowalczyk and I. Kowalik and B. Kozak-B{\l}a{\.z}kiewicz and M. Kozik and D. Koz{\l}owska and E. Koz{\l}owska and M. Koz{\l}owska and T. Kozubski and K. K{\'o}zka and L. Kra{\'s}nik and T. Kr{\c e}{\.z}el and B. Krochmal and B. Kr{\'o}l and G. Kr{\'o}l and J. Kr{\'o}l and T. Kr{\'o}likowska and H. Kruszewska and B. Krygier-Potrykus and W. Krystek and J. Krzyszto{\'n} and T. Kubicki and A. Kuczmierczyk-El-Hassan and W. Kuczy{\'n}ska-Witek and D. Kujda and A. Kurowski and I. Kurzelewska-Solarz and M. Kwaczy{\'n}ska and M. Kwa{\'s}niak and P. Kwa{\'s}niak and T. Kwietniewska and A. {\L}ebek-Ordon and A. Lebiedowicz and L. Lejkowska-Olszewska and M. Lentas and A. Lesiewicz-Ksyci{\'n}ska and M. Limanowski and S. {\L}oniewski and {\L}opata, {J. A.} and B. {\L}ubianka and I. {\L}ukasiuk and M. {\L}u{\.z}na and M. {\L}ysiak and B. {\L}ysik and Z. Machowski and J. Maciaczyk-Kubiak and G. Mackiewicz-Zabochnicka and Z. Magner-Kr{\c e}{\.z}el and S. Majda and P. Malinowski and J. Mantyka and E. Marchlik and G. Martyna-Ordyniec and J. Marzec and M. Marzec and R. Matejko-Wa{\l}kiewicz and M. Mazur and M. Michalczak and A. Michalska-{\.Z}y{\l}ka and M. Michniewicz and D. Mika-Staniszewska and E. Mikiciuk and T. Miko{\l}ajczak and J. Milewski and E. Miller and B. Misiaszek and M. Mizik-{\L}ukowska and E. M{\l}y{\'n}czyk-Pokutycka",

year = "2020",

month = nov,

doi = "10.1016/j.atherosclerosis.2020.08.026",

language = "English",

volume = "312",

pages = "16--22",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Lipid levels, atrial fibrillation and the impact of age

T2 - Results from the LIPIDOGRAM2015 study

AU - Harrison, Stephanie L.

AU - Lane, Deirdre A.

AU - Banach, Maciej

AU - Mastej, Mirosław

AU - Kasperczyk, Sławomir

AU - Jóźwiak, J. J.

AU - Lip, Gregory Y.H.

AU - LIPIDOGRAM2015 Investigators

AU - Al-Shaer, B.

AU - Andrusewicz, W.

AU - Andrzejczuk-Rosa, M.

AU - Anusz-Gaszewska, E.

AU - Bagińska, A.

AU - Balawajder, P.

AU - Bańka, G.

AU - Barańska-Skubisz, E.

AU - Barbara Przyczyna, B.

AU - Bartkowiak, S.

AU - Bartodziej, J.

AU - Bartosiewicz, M.

AU - Basałyga, M.

AU - Batyra, A.

AU - Bąk, A.

AU - Bednarz, M.

AU - Bejnar, K.

AU - Bernacki, W.

AU - Betiuk-Kwiatkowska, M.

AU - Biegaj, S.

AU - Bień, M.

AU - Bilski, W.

AU - Biłogan, M.

AU - Biruta-Pawłowska, G.

AU - Biskup, A.

AU - Błaszczyk, B.

AU - Błaszczyk, H.

AU - Błońska-Jankowska, T.

AU - Bogacka-Gancarczyk, B.

AU - Bojanowska, M.

AU - Bonda, E.

AU - Borowik-Skwarek, J.

AU - Borowska, J.

AU - Bruckner, J.

AU - Brzostek, J.

AU - Brzuchacz, M.

AU - Budzyńska, M.

AU - Bulzacka-Fugiel, I.

AU - Bulzak, J.

AU - Bunikowski, K.

AU - Cebulska, A.

AU - Celka, T.

AU - Cempel-Nowak, E.

AU - Chechliński, W.

AU - Chludzińska, A.

AU - Chmiel, D.

AU - Chmielewska, M.

AU - Cichy, M.

AU - Ciemięga, A.

AU - Ciepluch, A.

AU - Cieszyńska, I.

AU - Czajka, B.

AU - Czapla, B.

AU - Czerner, M.

AU - Czerwińska, B.

AU - Czuryszkiewicz, W.

AU - Daleka, E.

AU - Dawid, Z.

AU - Dąbrowska, M.

AU - Dąbrowska, R.

AU - Dąbrowski, D.

AU - Dąbrowski, M.

AU - Demczyszyn, K.

AU - Dębowska-Serwińska, A.

AU - Dmochowski, J.

AU - Dobrzecka-Kiwior, J.

AU - Dolanowska, E.

AU - Dolanowski, H.

AU - Dołek, P.

AU - Domagała, M.

AU - Domański, H.

AU - Doszel, A.

AU - Duda, D.

AU - Dudkowska, M.

AU - Dudziuk, B.

AU - Dybciak, P.

AU - Dymanowski, M.

AU - Dziadzio-Bolek, L.

AU - Eicke, M.

AU - El-Hassan, H.

AU - Eremus, A.

AU - Fąferek-Muller, M.

AU - Figura-Roguska, E.

AU - Fijałkowska-Kaczmarek, I.

AU - Flis, M.

AU - Florczak, T.

AU - Florczuk, M.

AU - Foryszewska-Witan, E.

AU - Frydrych, W.

AU - Fugiel, A.

AU - Futyma, E.

AU - Gaca-Jaroszewicz, A.

AU - Gajdamowicz, I.

AU - Ganczarski, K.

AU - Gatnar, A.

AU - Gers, M.

AU - Głowacki, A.

AU - Głód, K.

AU - Godula, J.

AU - Gołąb, J.

AU - Gołębiewski, M.

AU - Goszczyńska, E.

AU - Gościcka, K.

AU - Górna-Hajduga, A.

AU - Górny, E.

AU - Grabowska, T.

AU - Grabowski, R.

AU - Graczyk-Duda, A.

AU - Gromow, A.

AU - Grudewicz, A.

AU - Gruszecka, J.

AU - Gruszka, A.

AU - Gryboś, J.

AU - Grzebyk, J.

AU - Grzechowiak, A.

AU - Grzesiak, D.

AU - Grześkowiak, T.

AU - Guźla, A.

AU - Hachuła, G.

AU - Hawel, B.

AU - Hiltawska, H.

AU - Honkowicz, E.

AU - Ignatowicz, J.

AU - Imielski, K.

AU - Iwaniura, A.

AU - Jagieła-Szymala, A.

AU - Jalć-Sowała, M.

AU - Janczylik, A.

AU - Janisz, E.

AU - Janiszek, M.

AU - Jankiewicz-Ziobro, K.

AU - Januszewska, K.

AU - Jaremek, A.

AU - Jaros-Urbaniak, A.

AU - Jarosz, J.

AU - Jarosz, P.

AU - Jasiński, W.

AU - Jezierska-Wasilewska, M.

AU - Jędraszewski, T.

AU - Jędrzejowska, A.

AU - Józefowicz, R.

AU - Jóźwiak, J. J.

AU - Juźwin, K.

AU - Kacprzak, E.

AU - Kaczmarek-Szewczyk, J.

AU - Kaczmarzyk, M.

AU - Kandziora, R.

AU - Kaniewski, C.

AU - Karolak-Brandt, L.

AU - Kasperczyk, S.

AU - Kasperek-Dyląg, E.

AU - Kedziora, I.

AU - Kępa, A.

AU - Kiciński, J.

AU - Kielak-Al-Hosam, J.

AU - Kiełczawa,

AU - Kilimowicz, P.

AU - Kitliński, K.

AU - Kiwka, T.

AU - Klein, U.

AU - Klichowicz, L.

AU - Klimowicz, A.

AU - Klonowski, B.

AU - Kmolek, B.

AU - Kobyłko-Klepacka, E.

AU - Kocoń, A.

AU - Kolenda, A.

AU - Kollek, E.

AU - Kopeć, M.

AU - Koper-Kozikowska, B.

AU - Koralewska, J.

AU - Korczyńska, M.

AU - Korzeniewski, M. T.

AU - Kosk, A.

AU - Kotarski, K.

AU - Kowalczyk, E.

AU - Kowalczyk, M.

AU - Kowalik, I.

AU - Kozak-Błażkiewicz, B.

AU - Kozik, M.

AU - Kozłowska, D.

AU - Kozłowska, E.

AU - Kozłowska, M.

AU - Kozubski, T.

AU - Kózka, K.

AU - Kraśnik, L.

AU - Krężel, T.

AU - Krochmal, B.

AU - Król, B.

AU - Król, G.

AU - Król, J.

AU - Królikowska, T.

AU - Kruszewska, H.

AU - Krygier-Potrykus, B.

AU - Krystek, W.

AU - Krzysztoń, J.

AU - Kubicki, T.

AU - Kuczmierczyk-El-Hassan, A.

AU - Kuczyńska-Witek, W.

AU - Kujda, D.

AU - Kurowski, A.

AU - Kurzelewska-Solarz, I.

AU - Kwaczyńska, M.

AU - Kwaśniak, M.

AU - Kwaśniak, P.

AU - Kwietniewska, T.

AU - Łebek-Ordon, A.

AU - Lebiedowicz, A.

AU - Lejkowska-Olszewska, L.

AU - Lentas, M.

AU - Lesiewicz-Ksycińska, A.

AU - Limanowski, M.

AU - Łoniewski, S.

AU - Łopata, J. A.

AU - Łubianka, B.

AU - Łukasiuk, I.

AU - Łużna, M.

AU - Łysiak, M.

AU - Łysik, B.

AU - Machowski, Z.

AU - Maciaczyk-Kubiak, J.

AU - Mackiewicz-Zabochnicka, G.

AU - Magner-Krężel, Z.

AU - Majda, S.

AU - Malinowski, P.

AU - Mantyka, J.

AU - Marchlik, E.

AU - Martyna-Ordyniec, G.

AU - Marzec, J.

AU - Marzec, M.

AU - Matejko-Wałkiewicz, R.

AU - Mazur, M.

AU - Michalczak, M.

AU - Michalska-Żyłka, A.

AU - Michniewicz, M.

AU - Mika-Staniszewska, D.

AU - Mikiciuk, E.

AU - Mikołajczak, T.

AU - Milewski, J.

AU - Miller, E.

AU - Misiaszek, B.

AU - Mizik-Łukowska, M.

AU - Młyńczyk-Pokutycka, E.

PY - 2020/11

Y1 - 2020/11

N2 - Background and aims: An inverse relationship between lipid levels and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. Methods: Multivariate Poisson regression models were used to estimate prevalence ratios (PRs) for AF by lipid levels. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), non-HDL-C and LDL-C/HDL-C ratios were grouped into quartiles. Results: Of the 13,724 participants, 5.2% (n = 708) had AF. People with AF were older with more comorbidities, but lower lipid levels (all p < 0.05). The prevalence of AF was inversely associated with LDL-C (Adjusted PR (95% Confidence Interval) highest versus lowest quartile: 0.60 (0.48, 0.75)), TC (0.61 (0.49, 0.75)) and non-HDL-C (0.63 (0.51, 0.78)). The prevalence of AF was inversely associated with HDL-C (0.58 (0.46, 0.74)), but this was not statistically significant for people aged 75 years and older. For the LDL-C/HDL-C ratio, the prevalence of AF was only inversely associated with higher levels for people aged 75 years and older (0.75 (0.61, 0.94)). There was no statistically significant difference in prevalence of AF by TG levels. Conclusions: The results suggest an inverse relationship between lipid levels and AF. The inverse association between higher HDL-C and AF was only significant for people aged <75 years, whereas the inverse association between higher LDL-C/HDL-C ratio and AF was only significant for people aged 75 years and older.

AB - Background and aims: An inverse relationship between lipid levels and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. Methods: Multivariate Poisson regression models were used to estimate prevalence ratios (PRs) for AF by lipid levels. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), non-HDL-C and LDL-C/HDL-C ratios were grouped into quartiles. Results: Of the 13,724 participants, 5.2% (n = 708) had AF. People with AF were older with more comorbidities, but lower lipid levels (all p < 0.05). The prevalence of AF was inversely associated with LDL-C (Adjusted PR (95% Confidence Interval) highest versus lowest quartile: 0.60 (0.48, 0.75)), TC (0.61 (0.49, 0.75)) and non-HDL-C (0.63 (0.51, 0.78)). The prevalence of AF was inversely associated with HDL-C (0.58 (0.46, 0.74)), but this was not statistically significant for people aged 75 years and older. For the LDL-C/HDL-C ratio, the prevalence of AF was only inversely associated with higher levels for people aged 75 years and older (0.75 (0.61, 0.94)). There was no statistically significant difference in prevalence of AF by TG levels. Conclusions: The results suggest an inverse relationship between lipid levels and AF. The inverse association between higher HDL-C and AF was only significant for people aged <75 years, whereas the inverse association between higher LDL-C/HDL-C ratio and AF was only significant for people aged 75 years and older.

KW - Age

KW - Atrial fibrillation

KW - Cholesterol

KW - Epidemiology

KW - Lipids

KW - Prevalence

UR - http://www.scopus.com/inward/record.url?scp=85090729460&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2020.08.026

DO - 10.1016/j.atherosclerosis.2020.08.026

M3 - Article

C2 - 32947222

AN - SCOPUS:85090729460

SN - 0021-9150

VL - 312

SP - 16

EP - 22

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study

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Keywords

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