TY - JOUR
T1 - LIQUID GASTRIC EMPTYING ASSESSED BY DIRECT AND INDIRECT TECHNIQUES
T2 - RADIONUCLIDE LABELLED LIQUID EMPTYING COMPARED WITH A SIMPLE PARACETAMOL MARKER METHOD
AU - Maddern, Guy
AU - Miners, John
AU - Collins, Peter J.
AU - Jamieson, Glyn G.
PY - 1985/4
Y1 - 1985/4
N2 - Radionuclide techniques have enabled direct quantitative measurements of gastric emptying for solid and liquid phases of a meal. Such a technique has been used to validate the use of plasma paracetamol levels as a means of indirect assessment of liquid gastric emptying and to confirm a useful correlation exists between plasma and saliva paracetamol concentrations. Ten healthy volunteers underwent a routine gastric emptying study. The meal comprised a 100g ‘hamburger’ and 150 ml of 10% dextrose in water containing 113In and 1 g of dissolved paracetamol. The time taken for 50% of the liquid marker (T50) to clear the gastric region was assessed. Time to peak concentration of paracetamol for both saliva (C max‐saliva) and plasma (C max‐plasma) was determined. A significant correlation was found between the time to C max‐plasma and T50 (rs= 0.624, P < 0.05) and also time to C max‐saliva and T50 (rs= 0.573, P < 0.05), confirming that paracetamol concentration in plasma and saliva reflect radionuclide assessed liquid emptying. A useful correlation also exists between time to C max‐plasma and time to C max‐saliva (rs= 0.84, P < 0.01) permitting them to be used interchangeably. The use of time to C max‐saliva to assess liquid gastric emptying has a number of applications.
AB - Radionuclide techniques have enabled direct quantitative measurements of gastric emptying for solid and liquid phases of a meal. Such a technique has been used to validate the use of plasma paracetamol levels as a means of indirect assessment of liquid gastric emptying and to confirm a useful correlation exists between plasma and saliva paracetamol concentrations. Ten healthy volunteers underwent a routine gastric emptying study. The meal comprised a 100g ‘hamburger’ and 150 ml of 10% dextrose in water containing 113In and 1 g of dissolved paracetamol. The time taken for 50% of the liquid marker (T50) to clear the gastric region was assessed. Time to peak concentration of paracetamol for both saliva (C max‐saliva) and plasma (C max‐plasma) was determined. A significant correlation was found between the time to C max‐plasma and T50 (rs= 0.624, P < 0.05) and also time to C max‐saliva and T50 (rs= 0.573, P < 0.05), confirming that paracetamol concentration in plasma and saliva reflect radionuclide assessed liquid emptying. A useful correlation also exists between time to C max‐plasma and time to C max‐saliva (rs= 0.84, P < 0.01) permitting them to be used interchangeably. The use of time to C max‐saliva to assess liquid gastric emptying has a number of applications.
KW - liquid gastric emptying
KW - paracetamol
KW - plasma
KW - saliva
UR - http://www.scopus.com/inward/record.url?scp=0021829787&partnerID=8YFLogxK
U2 - 10.1111/j.1445-2197.1985.tb00885.x
DO - 10.1111/j.1445-2197.1985.tb00885.x
M3 - Article
C2 - 3862394
AN - SCOPUS:0021829787
VL - 55
SP - 203
EP - 206
JO - Australian and New Zealand Journal of Surgery
JF - Australian and New Zealand Journal of Surgery
SN - 0004-8682
IS - 2
ER -