Liver resection and transplantation offer similar 5-year survival for Child-Pugh-Turcotte A HCC-patients with a single nodule up to 5 cm: A multicenter, exploratory analysis

Mauricio Silva, Gonzalo Sapisochin, Simone Strasser, S Hewa-Geeganage, John Chen, Alan Wigg, Robert Jones, R Saraiva, Luciana Kikuchi, Flair Carrilho, Paulo Fontes, Ramon Charco

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Background and aim: The current guideline of the American Association for the Study of Liver Diseases recommends liver resection for Child-Pugh-Turcotte A patients with a single hepatocellular carcinoma, total serum bilirubin ≤1 mg/dL and absence of significant portal hypertension. This subset of patients would have a long-term survival comparable to transplantation. The main aim of this study is to evaluate the survival rates in patients with a single nodule ≤5 cm following resection. Methods: Medical records of 105 Child-Pugh-Turcotte A patients who underwent liver resection between 1997 and 2009 were analyzed in 3 countries. Results: One, 3-, and 5-year survival rate was 97%, 83%, and 66%, respectively, and no variable that can be assessed prior to liver resection predicted survival probabilities. Conclusions: Liver resection offers 5-year survival similar to transplantation for Child-Pugh-Turcotte A patients with hepatocellular carcinoma and a single nodule up to 5 cm, independently of any patient baseline characteristics.

    Original languageEnglish
    Pages (from-to)386-395
    Number of pages10
    JournalEJSO - European Journal of Surgical Oncology
    Volume39
    Issue number4
    DOIs
    Publication statusPublished - Apr 2013

    Keywords

    • Hepatocellular carcinoma
    • Liver resection
    • Liver transplantation

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