Local hypothalamic adrenoceptor activation in rat: α1 inhibits and α2 stimulates growth hormone secretion

John O. Willoughby, I. M. Chapman, Ranjna Kapoor

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    We made stereotaxic microinjections of adrenoceptor agonists and the catecholamine-releasing agent, tyramine, into the preoptic anterior hypothalamic area (PO/AHA) or the medial basal hypothalamus (MBH) of unstressed rats. Growth hormone (GH) plasma concentrations were measured serially before and after intrahypothalamic injections. Noradrenaline and phenylephrine inhibited GH secretion wherever injected but were effective at lower doses in the PO/AHA. Clonidine stimulated GH secretion at both sites, at several doses in the MBH and only at one dose in the PO/AHA. Tyramine inhibited GH when injected in the PO/AHA, but not in the MBH. We conclude: (a) α1 inhibition is predominant over α2 stimulation of GH on or near somatostatin neurons; (b) α2 stimulation predominates over α1 inhibition of GH on or near GRF neurons, and (c) endogenous catecholamines in the PO/AHA have a predominantly inhibitory effect on GH secretion.

    Original languageEnglish
    Pages (from-to)687-692
    Number of pages6
    JournalNeuroendocrinology
    Volume57
    Issue number4
    DOIs
    Publication statusPublished - 1993

    Keywords

    • Amygdala
    • Arcuate nucleus
    • GH-releasing factor
    • Growth hormone
    • Pharmacology
    • Preoptic area
    • Somatostatin
    • Tyramine
    • α- and ß-Adrenoceptor agonists

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