Localization of HLA-ABC and DR antigens in human kidney

Derek N.J. Hart, Susan V. Fuggle, Keryn A. Williams, John W. Fabre, Alan Ting, Peter J. Morris

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)


Monoclonal antibodies to human monomorphic class I and class II major histocompatibility complex (MHC) determinants have been used with immunofluorescence and immunoperoxidase techniques, to localize these an- tigens in normal human kidneys. HLA-DR antigen was located in the glomeruli (probably on endothelium as well as in the mesangium) and within the cells of cortical and medullary tubules. Dendritic cells in the renal inter- stitium stained brightly for the DR antigen and could be distinguished from the staining of capillary endothelium. The vascular endothelium of large vessels stained less densely for the HLA-DR antigen than for HLA-ABC an- tigens. The glomeruli stained intensely for the HLA-ABC antigens and diffuse staining of HLA-ABC antigens was also noted within renal tubular cells.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
Issue number6
Publication statusPublished - Jun 1981
Externally publishedYes


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