Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5

Donna Krasnewich, Christine A. Kozak, Daniel W. Nebert, Peter I. Mackenzie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3)and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse x Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3)to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalSomatic Cell and Molecular Genetics
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 1987
Externally publishedYes

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