Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5

Donna Krasnewich; Christine A. Kozak; Daniel W. Nebert; Peter I. Mackenzie

doi:10.1007/BF01534698

Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5

Donna Krasnewich, Christine A. Kozak, Daniel W. Nebert, Peter I. Mackenzie

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGT_r-3)and androsterone (UDPGT_r-4). In the present study, UDPGT_r-3 and UDPGT_r-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse x Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGT_r-3)to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Somatic Cell and Molecular Genetics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/BF01534698
Publication status	Published - 1 Mar 1987
Externally published	Yes

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abstract = "The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3)and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse x Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3)to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.",

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AB - The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3)and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse x Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3)to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.

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Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5

Abstract

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