Long-term immunosuppression after liver transplantation: are steroids necessary?

R. T. A. Padbury; B. K. Gunson; B. Dousset; S. G. Hubscher; A. D. Mayer; J. A. Buckels; J. M. Neuberger; E. Elias; P. McMaster

doi:10.1111/tri.1992.5.s1.470

Long-term immunosuppression after liver transplantation: are steroids necessary?

R. T. A. Padbury, B. K. Gunson, B. Dousset, S. G. Hubscher, A. D. Mayer, J. A. Buckels, J. M. Neuberger, E. Elias, P. McMaster

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.

Original language	English
Pages (from-to)	S470-S472
Number of pages	3
Journal	Transplant international : official journal of the European Society for Organ Transplantation
Volume	5
Issue number	S1
DOIs	https://doi.org/10.1111/tri.1992.5.s1.470
Publication status	Published - 1992
Externally published	Yes

Access to Document

10.1111/tri.1992.5.s1.470Licence: In Copyright

Cite this

Padbury, R. T. A., Gunson, B. K., Dousset, B., Hubscher, S. G., Mayer, A. D., Buckels, J. A., Neuberger, J. M., Elias, E., & McMaster, P. (1992). Long-term immunosuppression after liver transplantation: are steroids necessary? Transplant international : official journal of the European Society for Organ Transplantation, 5(S1), S470-S472. https://doi.org/10.1111/tri.1992.5.s1.470

@article{b447c133355f46e6a3cc0632be7f5e80,

title = "Long-term immunosuppression after liver transplantation: are steroids necessary?",

abstract = "Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.",

author = "Padbury, {R. T. A.} and Gunson, {B. K.} and B. Dousset and Hubscher, {S. G.} and Mayer, {A. D.} and Buckels, {J. A.} and Neuberger, {J. M.} and E. Elias and P. McMaster",

year = "1992",

doi = "10.1111/tri.1992.5.s1.470",

language = "English",

volume = "5",

pages = "S470--S472",

journal = "TRANSPLANT INTERNATIONAL",

issn = "0934-0874",

number = "S1",

}

Padbury, RTA, Gunson, BK, Dousset, B, Hubscher, SG, Mayer, AD, Buckels, JA, Neuberger, JM, Elias, E & McMaster, P 1992, 'Long-term immunosuppression after liver transplantation: are steroids necessary?', Transplant international : official journal of the European Society for Organ Transplantation, vol. 5, no. S1, pp. S470-S472. https://doi.org/10.1111/tri.1992.5.s1.470

Long-term immunosuppression after liver transplantation : are steroids necessary? / Padbury, R. T. A.; Gunson, B. K.; Dousset, B.; Hubscher, S. G.; Mayer, A. D.; Buckels, J. A.; Neuberger, J. M.; Elias, E.; McMaster, P.

In: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 5, No. S1, 1992, p. S470-S472.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Long-term immunosuppression after liver transplantation

T2 - are steroids necessary?

AU - Padbury, R. T. A.

AU - Gunson, B. K.

AU - Dousset, B.

AU - Hubscher, S. G.

AU - Mayer, A. D.

AU - Buckels, J. A.

AU - Neuberger, J. M.

AU - Elias, E.

AU - McMaster, P.

PY - 1992

Y1 - 1992

N2 - Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.

AB - Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.

UR - http://www.scopus.com/inward/record.url?scp=3242831927&partnerID=8YFLogxK

U2 - 10.1111/tri.1992.5.s1.470

DO - 10.1111/tri.1992.5.s1.470

M3 - Article

C2 - 14621849

AN - SCOPUS:3242831927

VL - 5

SP - S470-S472

JO - TRANSPLANT INTERNATIONAL

JF - TRANSPLANT INTERNATIONAL

SN - 0934-0874

IS - S1

ER -

Long-term immunosuppression after liver transplantation: are steroids necessary?

Abstract

Access to Document

Other files and links

Fingerprint

Cite this