Long-term immunosuppression after liver transplantation: are steroids necessary?

R. T. A. Padbury; B. K. Gunson; B. Dousset; S. G. Hubscher; A. D. Mayer; J. A. Buckels; J. M. Neuberger; E. Elias; P. McMaster

doi:10.1111/tri.1992.5.s1.470

Long-term immunosuppression after liver transplantation: are steroids necessary?

R. T. A. Padbury, B. K. Gunson, B. Dousset, S. G. Hubscher, A. D. Mayer, J. A. Buckels, J. M. Neuberger, E. Elias, P. McMaster

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.

Original language	English
Pages (from-to)	S470-S472
Number of pages	3
Journal	Transplant international : official journal of the European Society for Organ Transplantation
Volume	5
Issue number	S1
DOIs	https://doi.org/10.1111/tri.1992.5.s1.470
Publication status	Published - 1992
Externally published	Yes

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Padbury, R. T. A., Gunson, B. K., Dousset, B., Hubscher, S. G., Mayer, A. D., Buckels, J. A., Neuberger, J. M., Elias, E., & McMaster, P. (1992). Long-term immunosuppression after liver transplantation: are steroids necessary? Transplant international : official journal of the European Society for Organ Transplantation, 5(S1), S470-S472. https://doi.org/10.1111/tri.1992.5.s1.470

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title = "Long-term immunosuppression after liver transplantation: are steroids necessary?",

abstract = "Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.",

author = "Padbury, {R. T. A.} and Gunson, {B. K.} and B. Dousset and Hubscher, {S. G.} and Mayer, {A. D.} and Buckels, {J. A.} and Neuberger, {J. M.} and E. Elias and P. McMaster",

year = "1992",

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Padbury, RTA, Gunson, BK, Dousset, B, Hubscher, SG, Mayer, AD, Buckels, JA, Neuberger, JM, Elias, E & McMaster, P 1992, 'Long-term immunosuppression after liver transplantation: are steroids necessary?', Transplant international : official journal of the European Society for Organ Transplantation, vol. 5, no. S1, pp. S470-S472. https://doi.org/10.1111/tri.1992.5.s1.470

Long-term immunosuppression after liver transplantation : are steroids necessary? / Padbury, R. T. A.; Gunson, B. K.; Dousset, B.; Hubscher, S. G.; Mayer, A. D.; Buckels, J. A.; Neuberger, J. M.; Elias, E.; McMaster, P.

In: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 5, No. S1, 1992, p. S470-S472.

Research output: Contribution to journal › Article › peer-review

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