Long-term immunosuppression after liver transplantation: are steroids necessary?

R. T. A. Padbury, B. K. Gunson, B. Dousset, S. G. Hubscher, A. D. Mayer, J. A. Buckels, J. M. Neuberger, E. Elias, P. McMaster

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Steroid therapy was withdrawn in 85% of 152 orthotopic liver transplant recipients with grafts surviving for more than 3 months, and 87% of these remained steroid-free. Steroid therapy was restarted in 8% for reasons other than rejection. The most common was conversion of immunosuppression because of cyclosporine nephrotoxicity. The incidence of rejection after steroid withdrawal was low: 3.8% for chronic rejection (CR) and 4.5% for acute rejection. Only 3 grafts (1.9%) were lost because of CR. No risk factors have been identified for the development of CR after steroid withdrawal, but a protective role for azathioprine has been suggested.

Original languageEnglish
Pages (from-to)S470-S472
Number of pages3
JournalTransplant international : official journal of the European Society for Organ Transplantation
Volume5
Issue numberS1
DOIs
Publication statusPublished - 1992
Externally publishedYes

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