Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome

Chris Mavrangelos; Melissa A. Campaniello; Jane M. Andrews; Peter A. Bampton; Patrick A. Hughes

doi:10.1136/gutjnl-2017-314308

Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome

Chris Mavrangelos, Melissa A. Campaniello, Jane M. Andrews, Peter A. Bampton, Patrick A. Hughes

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The recent study by Wouters et al1reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptomfree and when they experience symptomflare.

Original language	English
Pages (from-to)	397-398
Number of pages	2
Journal	Gut
Volume	67
Issue number	2
DOIs	https://doi.org/10.1136/gutjnl-2017-314308
Publication status	Published - Feb 2018
Externally published	Yes

Keywords

irritable bowel syndrome
Bowel Disease Questionnaire
correspondence

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title = "Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome",

abstract = "The recent study by Wouters et al1reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptomfree and when they experience symptomflare.",

keywords = "irritable bowel syndrome, Bowel Disease Questionnaire, correspondence",

author = "Chris Mavrangelos and Campaniello, {Melissa A.} and Andrews, {Jane M.} and Bampton, {Peter A.} and Hughes, {Patrick A.}",

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T1 - Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome

AU - Mavrangelos, Chris

AU - Campaniello, Melissa A.

AU - Andrews, Jane M.

AU - Bampton, Peter A.

AU - Hughes, Patrick A.

PY - 2018/2

Y1 - 2018/2

N2 - The recent study by Wouters et al1reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptomfree and when they experience symptomflare.

AB - The recent study by Wouters et al1reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptomfree and when they experience symptomflare.

KW - irritable bowel syndrome

KW - Bowel Disease Questionnaire

KW - correspondence

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UR - http://purl.org/au-research/grants/NHMRC/1042952

UR - http://purl.org/au-research/grants/NHMRC/1105028

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DO - 10.1136/gutjnl-2017-314308

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VL - 67

SP - 397

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JO - Gut

JF - Gut

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Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome

Abstract

Keywords

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