Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome

Chris Mavrangelos, Melissa A. Campaniello, Jane M. Andrews, Peter A. Bampton, Patrick A. Hughes

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The recent study by Wouters et al1reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptomfree and when they experience symptomflare.
Original languageEnglish
Pages (from-to)397-398
Number of pages2
JournalGut
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2018
Externally publishedYes

Keywords

  • irritable bowel syndrome
  • Bowel Disease Questionnaire
  • correspondence

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