TY - JOUR
T1 - Low ambient temperature and intracerebral hemorrhage
T2 - The INTERACT2 study
AU - Zheng, Danni
AU - Arima, Hisatomi
AU - Sato, Shoichiro
AU - Gasparrini, Antonio
AU - Heeley, Emma
AU - Delcourt, Candice
AU - Lo, Serigne
AU - Huang, Yining
AU - Wang, Jiguang
AU - Stapf, Christian
AU - Robinson, Thompson
AU - Lavados, Pablo
AU - Chalmers, John
AU - Anderson, Craig S.
AU - INTERACT2 Investigators
N1 - Copyright: © 2016 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/2/9
Y1 - 2016/2/9
N2 - BackgroundRates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown.We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. Methods INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95%CI. Results Low ambient temperature (10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for-10°C, and 5.76 (2.30-14.42) for-20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. Conclusions Exposure to low ambient temperature within several hours increases the risk of ICH.
AB - BackgroundRates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown.We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. Methods INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95%CI. Results Low ambient temperature (10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for-10°C, and 5.76 (2.30-14.42) for-20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. Conclusions Exposure to low ambient temperature within several hours increases the risk of ICH.
KW - low ambient temperature
KW - INTERACT2 Study
KW - intracerebral hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=84959212169&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0149040
DO - 10.1371/journal.pone.0149040
M3 - Article
C2 - 26859491
AN - SCOPUS:84959212169
SN - 1932-6203
VL - 11
JO - PLoS One
JF - PLoS One
IS - 2
M1 - e0149040
ER -