Abstract
Rheumatoid arthritis is a chronic inflammatory disorder resulting in bone and
cartilage destruction. Bone loss has been attributed to the relative increase in the
number and activity of bone-resorbing osteoclasts and the activation of NF-kappaB..
Caffeic acid phenethyl ester (CAPE) is a natural bioactive compound from the
propolis of honeybee hives, which inhibits NFkappa B activity (Ang J Cell Physiol
2009) and has anti-inflammatory and immunomodulatory properties. We have shown
inhibition of bone resorption with low doses of CAPE (1mg/kg/day) in a wear particle
induced calvarial model of osteolysis (Zawawi Cal Tiss Int 2015).
cartilage destruction. Bone loss has been attributed to the relative increase in the
number and activity of bone-resorbing osteoclasts and the activation of NF-kappaB..
Caffeic acid phenethyl ester (CAPE) is a natural bioactive compound from the
propolis of honeybee hives, which inhibits NFkappa B activity (Ang J Cell Physiol
2009) and has anti-inflammatory and immunomodulatory properties. We have shown
inhibition of bone resorption with low doses of CAPE (1mg/kg/day) in a wear particle
induced calvarial model of osteolysis (Zawawi Cal Tiss Int 2015).
| Original language | English |
|---|---|
| Pages | 487 |
| Number of pages | 1 |
| Publication status | Published - 17 Dec 2015 |
| Event | American Society for Bone and Mineral Research (ASBMR) Annual Meeting - Seattle, United States Duration: 9 Oct 2015 → 12 Oct 2015 https://www.asbmr.org/education/abstracts |
Conference
| Conference | American Society for Bone and Mineral Research (ASBMR) Annual Meeting |
|---|---|
| Abbreviated title | ASBMR 2015 |
| Country/Territory | United States |
| City | Seattle |
| Period | 9/10/15 → 12/10/15 |
| Internet address |
Keywords
- micro-CT
- inflammatory arthritis
- rheumatoid arthritis