Low dose CAPE treatment in a CAIA model of Inflammatory Arthritis

Bonnie Williams, Helen Tsangari, Melissa Cantley, Victor Marino, Jiake Xu, Egon Perilli, A. Kencana Dharmapatni, Tania Crotti

    Research output: Contribution to conferenceAbstract

    Abstract

    Rheumatoid arthritis is a chronic inflammatory disorder resulting in bone and
    cartilage destruction. Bone loss has been attributed to the relative increase in the
    number and activity of bone-resorbing osteoclasts and the activation of NF-kappaB..
    Caffeic acid phenethyl ester (CAPE) is a natural bioactive compound from the
    propolis of honeybee hives, which inhibits NFkappa B activity (Ang J Cell Physiol
    2009) and has anti-inflammatory and immunomodulatory properties. We have shown
    inhibition of bone resorption with low doses of CAPE (1mg/kg/day) in a wear particle
    induced calvarial model of osteolysis (Zawawi Cal Tiss Int 2015).
    Original languageEnglish
    Pages487
    Number of pages1
    Publication statusPublished - 17 Dec 2015
    EventAmerican Society for Bone and Mineral Research (ASBMR) Annual Meeting - Seattle, United States
    Duration: 9 Oct 201512 Oct 2015
    https://www.asbmr.org/education/abstracts

    Conference

    ConferenceAmerican Society for Bone and Mineral Research (ASBMR) Annual Meeting
    Abbreviated titleASBMR 2015
    CountryUnited States
    CitySeattle
    Period9/10/1512/10/15
    Internet address

    Keywords

    • micro-CT
    • inflammatory arthritis
    • rheumatoid arthritis

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  • Cite this

    Williams, B., Tsangari, H., Cantley, M., Marino, V., Xu, J., Perilli, E., Dharmapatni, A. K., & Crotti, T. (2015). Low dose CAPE treatment in a CAIA model of Inflammatory Arthritis. 487. Abstract from American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Seattle, United States.