Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

Floriane Calocer; Huah Shin Ng; Feng Zhu; Yinshan Zhao; Olivier Dejardin; Emmanuelle Leray; Gilles Defer; Charity Evans; John D. Fisk; Ruth Ann Marrie; Helen Tremlett

doi:10.1177/13524585221129963

Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett

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Abstract

Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood.

Objective: To investigate the association between SES and mortality risk in PwMS.

Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS ‘onset’) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality.

Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived).

Conclusion: A lower SES was associated with higher mortality risk in PwMS.

Original language	English
Pages (from-to)	466-470
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	29
Issue number	3
Early online date	25 Oct 2022
DOIs	https://doi.org/10.1177/13524585221129963
Publication status	Published - Mar 2023
Externally published	Yes

Keywords

mortality risk
Multiple sclerosis
population-based study
socioeconomic disparities
socioeconomic status

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Final published versionFinal published version, 426 KBLicence: CC BY

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@article{92ffcf7155df473880c15df27310f151,

title = "Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis",

abstract = "Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. Objective: To investigate the association between SES and mortality risk in PwMS.Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS {\textquoteleft}onset{\textquoteright}) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). Conclusion: A lower SES was associated with higher mortality risk in PwMS.",

keywords = "mortality risk, Multiple sclerosis, population-based study, socioeconomic disparities, socioeconomic status",

author = "Floriane Calocer and Ng, {Huah Shin} and Feng Zhu and Yinshan Zhao and Olivier Dejardin and Emmanuelle Leray and Gilles Defer and Charity Evans and Fisk, {John D.} and Marrie, {Ruth Ann} and Helen Tremlett",

year = "2023",

month = mar,

doi = "10.1177/13524585221129963",

language = "English",

volume = "29",

pages = "466--470",

journal = "Multiple Sclerosis",

issn = "1352-4585",

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TY - JOUR

T1 - Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

AU - Calocer, Floriane

AU - Ng, Huah Shin

AU - Zhu, Feng

AU - Zhao, Yinshan

AU - Dejardin, Olivier

AU - Leray, Emmanuelle

AU - Defer, Gilles

AU - Evans, Charity

AU - Fisk, John D.

AU - Marrie, Ruth Ann

AU - Tremlett, Helen

PY - 2023/3

Y1 - 2023/3

N2 - Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. Objective: To investigate the association between SES and mortality risk in PwMS.Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS ‘onset’) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). Conclusion: A lower SES was associated with higher mortality risk in PwMS.

AB - Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. Objective: To investigate the association between SES and mortality risk in PwMS.Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS ‘onset’) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). Conclusion: A lower SES was associated with higher mortality risk in PwMS.

KW - mortality risk

KW - Multiple sclerosis

KW - population-based study

KW - socioeconomic disparities

KW - socioeconomic status

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DO - 10.1177/13524585221129963

M3 - Article

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SN - 1352-4585

VL - 29

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JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 3

ER -

Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

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