Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
32 Downloads (Pure)


Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. 

Objective: To investigate the association between SES and mortality risk in PwMS.

Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS ‘onset’) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. 

Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). 

Conclusion: A lower SES was associated with higher mortality risk in PwMS.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalMultiple Sclerosis Journal
Issue number3
Early online date25 Oct 2022
Publication statusPublished - Mar 2023
Externally publishedYes


  • mortality risk
  • Multiple sclerosis
  • population-based study
  • socioeconomic disparities
  • socioeconomic status


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