Low-wavenumber Raman spectral database of pharmaceutical excipients

Kārlis Bērziņš, Ruth E. Sales, Jonathan E. Barnsley, Greg Walker, Sara J. Fraser-Miller, Keith C. Gordon

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The interest in applications of low-wavenumber Raman (LWR) spectroscopy for pharmaceutical analysis has increased rapidly over the last decade. In this study, a collection of LWR spectra are presented for 75 commonly used pharmaceutical excipients, which serve an important role in the manufacture and delivery of pharmaceutics. The excipients were divided into 10 main groups based on chemical composition: amino acids, mono- and disaccharides, polysaccharides, monomeric polyols, esters, inorganic substances, organosulfates and carboxylic acids/salts, protein, polymers and others. The spectral data is intended to serve as a reference for a number of general purposes such as qualitative and quantitative analysis, counterfeit detection and pharmaceutical process control.
Original languageEnglish
Article number103021
Number of pages11
JournalVibrational Spectroscopy
Volume107
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

Keywords

  • Excipients
  • Low-wavenumber Raman spectroscopy
  • Pharmaceuticals
  • Spectral database

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