Luminal Chemoreceptors and Intrinsic Nerves: Key Modulators of Digestive Motor Function

John Dent, Phil G. Dinning

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter reviews data on the pathways by which luminal, mainly duodenal, chemoreceptors modulate gastro-pyloro-duodenal motor function to control emptying of nutrients into the small intestine. The vagus mediates proximal gastric relaxation caused by nutrient stimulation of duodenal/jejunal mucosal chemoreceptors. Modulation of the spatial patterning and inhibition of antral contractions during duodenal chemoreceptor activation are somewhat conflicting: both vagal control and ascending intramural nerves appear to play a role. Intraduodenal nutrients stimulate the localized pyloric contractions that prevent transpyloric flow via ascending duodenal intramural nerve pathways. Though not yet formally investigated, patterns of activation of the duodenal brake motor mechanism suggest that duodenal loop mucosal chemoreceptors signal to a brake mechanism at the most aborad region of the duodenum via descending intramural duodenal nerves. Intrinsic intramural pathways are important in the control of the first stages of digestion.

Original languageEnglish
Title of host publicationThe Enteric Nervous System II
EditorsNick J. Spencer, Marcello Costa, Stuart M. Brierley
Place of PublicationSwitzerland
Number of pages13
ISBN (Electronic)978-3-031-05843-1
ISBN (Print)978-3-031-05842-4
Publication statusPublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Chemoreceptor
  • Duodenum
  • Jejunum
  • Motility
  • Vagus


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