Lymphopenia and lymphocyte transformation in alcoholics

G. P. Young, M. B. Van der Weyden, I. S. Rose, F. J. Dudley

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.

Original languageEnglish
Pages (from-to)268-269
Number of pages2
JournalExperientia
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Feb 1979
Externally publishedYes

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    Young, G. P., Van der Weyden, M. B., Rose, I. S., & Dudley, F. J. (1979). Lymphopenia and lymphocyte transformation in alcoholics. Experientia, 35(2), 268-269. https://doi.org/10.1007/BF01920656