Lymphopenia and lymphocyte transformation in alcoholics

G. P. Young, M. B. Van der Weyden, I. S. Rose, F. J. Dudley

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.

Original languageEnglish
Pages (from-to)268-269
Number of pages2
Issue number2
Publication statusPublished - 1 Feb 1979
Externally publishedYes


Dive into the research topics of 'Lymphopenia and lymphocyte transformation in alcoholics'. Together they form a unique fingerprint.

Cite this