Lytic to temperate switching of viral communities

B. Knowles, C. B. Silveira, B. A. Bailey, K. Barott, V. A. Cantu, A. G. Cobian-Guëmes, F. H. Coutinho, E. A. Dinsdale, B. Felts, K. A. Furby, E. E. George, K. T. Green, G. B. Gregoracci, A. F. Haas, J. M. Haggerty, E. R. Hester, N. Hisakawa, L. W. Kelly, Y. W. Lim, M. LittleA. Luque, T. McDole-Somera, K. McNair, L. S. De Oliveira, S. D. Quistad, N. L. Robinett, E. Sala, P. Salamon, S. E. Sanchez, S. Sandin, G. G.Z. Silva, J. Smith, C. Sullivan, C. Thompson, M. J.A. Vermeij, M. Youle, C. Young, B. Zgliczynski, R. Brainard, R. A. Edwards, J. Nulton, F. Thompson, F. Rohwer

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Microbial viruses can control host abundances via density-dependent lytic predator-prey dynamics. Less clear is how temperate viruses, which coexist and replicate with their host, influence microbial communities. Here we show that virus-like particles are relatively less abundant at high host densities. This suggests suppressed lysis where established models predict lytic dynamics are favoured. Meta-analysis of published viral and microbial densities showed that this trend was widespread in diverse ecosystems ranging from soil to freshwater to human lungs. Experimental manipulations showed viral densities more consistent with temperate than lytic life cycles at increasing microbial abundance. An analysis of 24 coral reef viromes showed a relative increase in the abundance of hallmark genes encoded by temperate viruses with increased microbial abundance. Based on these four lines of evidence, we propose the Piggyback-the-Winner model wherein temperate dynamics become increasingly important in ecosystems with high microbial densities; thus 'more microbes, fewer viruses'.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalNature
Volume531
Issue number7595
DOIs
Publication statusPublished - 24 Mar 2016
Externally publishedYes

Keywords

  • Coral reefs
  • Microbial biooceanography
  • Microbial ecology

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    Knowles, B., Silveira, C. B., Bailey, B. A., Barott, K., Cantu, V. A., Cobian-Guëmes, A. G., Coutinho, F. H., Dinsdale, E. A., Felts, B., Furby, K. A., George, E. E., Green, K. T., Gregoracci, G. B., Haas, A. F., Haggerty, J. M., Hester, E. R., Hisakawa, N., Kelly, L. W., Lim, Y. W., ... Rohwer, F. (2016). Lytic to temperate switching of viral communities. Nature, 531(7595), 466-470. https://doi.org/10.1038/nature17193