TY - JOUR
T1 - Magnetic Fe3O4@ZIF-8 nanoparticles as a drug release vehicle
T2 - pH-sensitive release of norfloxacin and its antibacterial activity
AU - Cai, Wanling
AU - Zhang, Wei
AU - Chen, Zuliang
PY - 2023/3
Y1 - 2023/3
N2 - Metal-organic frameworks (MOFs) have a high specific surface area and inherent biodegradability due to their unique structure and composition. As well, owing to the properties of nanomaterials and especially their magnetic features, Fe3O4 nanoparticles and MOFs composite materials have great potential in the design and application of drug release. The present work: firstly, investigated norfloxacin loading in magnetic metal organic framework (Fe3O4@ZIF-8); and secondly, studied the release of norfloxacin and its antibacterial activity. Results showed the release efficiencies reached 97 % at 310 K after 84 h (pH 7.4). Drug release behavior was tested at various pH levels and it was found that Fe3O4@ZIF-8 has pH-sensitive properties. Furthermore, the release model calculation illustrated that the release process fitted well to the Bhaskar model. The magnetic properties of Fe3O4@ZIF-8 confirmed that the composite has potential application for a targeted drug delivery system. The mechanism of pH-responsive norfloxacin release was combined with diffusion, ion exchange and electrostatic repulsion. Furthermore, the antibacterial activities of Fe3O4@ZIF-8 and NOR-Fe3O4@ZIF-8 were tested against Escherichia coli. Results showed that Fe3O4@ZIF-8 had good biocompatibility while NOR-Fe3O4@ZIF-8 can deter or inhibit the actions of microorganisms.
AB - Metal-organic frameworks (MOFs) have a high specific surface area and inherent biodegradability due to their unique structure and composition. As well, owing to the properties of nanomaterials and especially their magnetic features, Fe3O4 nanoparticles and MOFs composite materials have great potential in the design and application of drug release. The present work: firstly, investigated norfloxacin loading in magnetic metal organic framework (Fe3O4@ZIF-8); and secondly, studied the release of norfloxacin and its antibacterial activity. Results showed the release efficiencies reached 97 % at 310 K after 84 h (pH 7.4). Drug release behavior was tested at various pH levels and it was found that Fe3O4@ZIF-8 has pH-sensitive properties. Furthermore, the release model calculation illustrated that the release process fitted well to the Bhaskar model. The magnetic properties of Fe3O4@ZIF-8 confirmed that the composite has potential application for a targeted drug delivery system. The mechanism of pH-responsive norfloxacin release was combined with diffusion, ion exchange and electrostatic repulsion. Furthermore, the antibacterial activities of Fe3O4@ZIF-8 and NOR-Fe3O4@ZIF-8 were tested against Escherichia coli. Results showed that Fe3O4@ZIF-8 had good biocompatibility while NOR-Fe3O4@ZIF-8 can deter or inhibit the actions of microorganisms.
KW - Antibacterial activity
KW - Drug release
KW - FeO
KW - Norfloxacin
KW - ZIF-8
UR - http://www.scopus.com/inward/record.url?scp=85146656190&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2023.113170
DO - 10.1016/j.colsurfb.2023.113170
M3 - Article
C2 - 36696823
AN - SCOPUS:85146656190
SN - 0927-7765
VL - 223
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 113170
ER -