Manganese uptake and streptococcal virulence

Bart A. Eijkelkamp, Christopher A. McDevitt, Todd Kitten

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Streptococcal solute-binding proteins (SBPs) associated with ATP-binding cassette transporters gained widespread attention first as ostensible adhesins, next as virulence determinants, and finally as metal ion transporters. In this mini-review, we will examine our current understanding of the cellular roles of these proteins, their contribution to metal ion homeostasis, and their crucial involvement in mediating streptococcal virulence. There are now more than 35 studies that have collected structural, biochemical and/or physiological data on the functions of SBPs across a broad range of bacteria. This offers a wealth of data to clarify the formerly puzzling and contentious findings regarding the metal specificity amongst this group of essential bacterial transporters. In particular we will focus on recent findings related to biological roles for manganese in streptococci. These advances will inform efforts aimed at exploiting the importance of manganese and manganese acquisition for the design of new approaches to combat serious streptococcal diseases.

Original languageEnglish
Pages (from-to)491-508
Number of pages18
Issue number3
Early online date5 Feb 2015
Publication statusPublished - Jun 2015
Externally publishedYes


  • ABC transporter
  • Cluster A-I SBP
  • Manganese
  • Metal binding
  • Solute-binding protein
  • Streptococcus
  • Virulence
  • Zinc


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