Abstract
Background/Purpose: Infiltration of monocyte-derived macrophages into the synovial tissue (ST) is a hallmark of rheumatoid arthritis (RA). These infiltrating cells lead to inflammation, local joint effusion, and joint damage via the production of inflammatory cytokines. Macrophages express an array of co-stimulatory receptors, particularly those of the B7 protein family, including the programmed death protein 1 (PD-1) ligands, PD-L1 and PD-L2, and the B7-related protein VSIG4.
Original language | English |
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Number of pages | 2 |
Publication status | Published - 2021 |
Event | American College of Rheumatology Convergence 2021 - Virtual, United States Duration: 5 Nov 2021 → 9 Nov 2021 |
Conference
Conference | American College of Rheumatology Convergence 2021 |
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Abbreviated title | ACR Convergence 2021 |
Country/Territory | United States |
Period | 5/11/21 → 9/11/21 |
Keywords
- Rheumatoid arthritis
- Synovial tissue
- Macrophages
- B7 protein