Manipulation of B7 Family Member Expression Demonstrates Synovial Macrophage Plasticity and Possible Future Targets for Treatment of Rheumatoid Arthritis

Annabelle Small, Katie Williams, Antonio Ferrante, Malcolm Smith, Susanna Proudman, Helen Weedon, Mihir Wechalekar

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Background/Purpose: Infiltration of monocyte-derived macrophages into the synovial tissue (ST) is a hallmark of rheumatoid arthritis (RA). These infiltrating cells lead to inflammation, local joint effusion, and joint damage via the production of inflammatory cytokines. Macrophages express an array of co-stimulatory receptors, particularly those of the B7 protein family, including the programmed death protein 1 (PD-1) ligands, PD-L1 and PD-L2, and the B7-related protein VSIG4.
Original languageEnglish
Number of pages2
Publication statusPublished - 2021
EventAmerican College of Rheumatology Convergence 2021 - Virtual, United States
Duration: 5 Nov 20219 Nov 2021

Conference

ConferenceAmerican College of Rheumatology Convergence 2021
Abbreviated titleACR Convergence 2021
Country/TerritoryUnited States
Period5/11/219/11/21

Keywords

  • Rheumatoid arthritis
  • Synovial tissue
  • Macrophages
  • B7 protein

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