@article{4aa3db7014f04305a342bce1182e01e7,
title = "Mapping the Paediatric Quality of Life Inventory (PedsQL{\texttrademark}) Generic Core Scales onto the Child Health Utility Index–9 Dimension (CHU-9D) Score for Economic Evaluation in Children",
abstract = "Background: The Paediatric Quality of Life Inventory (PedsQL{\texttrademark}) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost–utility analysis. The Child Health Utility Index–9 Dimension (CHU-9D), however, is a preference-based instrument that has been primarily developed to support cost–utility analysis. Objective: This paper presents a method for estimating CHU-9D index scores from responses to the PedsQL{\texttrademark} using data from a randomised controlled trial of prednisolone therapy for treatment of childhood corticosteroid-sensitive nephrotic syndrome. Methods: HRQoL data were collected from children at randomisation, week 16, and months 12, 18, 24, 36 and 48. Observations on children aged 5 years and older were pooled across all data collection timepoints and were then randomised into an estimation (n = 279) and validation (n = 284) sample. A number of models were developed using the estimation data before internal validation. The best model was chosen using multi-stage selection criteria. Results: Most of the models developed accurately predicted the CHU-9D mean index score. The best performing model was a generalised linear model (mean absolute error = 0.0408; mean square error = 0.0035). The proportion of index scores deviating from the observed scores by OpenSPiltSPi 0.03 was 53%. Conclusions: The mapping algorithm provides an empirical tool for estimating CHU-9D index scores and for conducting cost–utility analyses within clinical studies that have only collected PedsQL{\texttrademark} data. It is valid for children aged 5 years or older. Caution should be exercised when using this with children younger than 5 years, older adolescents (CloseSPigtSPi 13 years) or patient groups with particularly poor quality of life. ISRCTN Registry No: 16645249.",
keywords = "PedsQL, Paediatric Quality of Life Inventory, health-related quality of life, Child Health Utility Index",
author = "Tosin Lambe and Emma Frew and Ives, {Natalie J.} and Woolley, {Rebecca L.} and Carole Cummins and Brettell, {Elizabeth A.} and Barsoum, {Emma N.} and Webb, {N. J.A.} and {On behalf of the PREDNOS Trial Team} and M. James-Ellison and Williams, {H. M.} and P. Bala and C. Jones and R. Holt and H. Morgan and E. Bailey and L. Flanagan and T. Bhatti and S. Bahl and L. Walding and E. Gouta and R. Gupta and D. Kerrin and A. Parikh and A. Duthie and N. Gadong and B. Anjum and B. Crone and {De Jesus}, H. and I. Lancoma-Malcolm and N. Plaatjies and K. Khalifa and K. McKeever and G. McCall and P. McCreesh and M. Millar and M. Hesseling and M. Kubwalo and A. Bolger and L. Hobson and D. Milford and L. Kerecuk and C. Norton and N. Rahania and H. Williamson and F. Bibi and T. Gazeley and J. Williams and F. Watson and C. Abbot and S. Frazer and L. Akeroyd and M. Ahmed and D. Muogbo and C. Backhouse and S. Boswell and E. Crosbie and P. Heinz and B. Ulbrich and S. Hegde and P. Jones and Webb, {N. J.A.} and R. Lennon and M. Lewis and N. Plant and M. Shenoy and S. Sukthankar and C. Bryant and S. Douglas and H. Sumner and J. Howell and N. Elhadi and I. Bishton and O. Ayonrinde and A. Turner and J. Campbell and A. Turner and J. Gibbs and E. Newby and S. Saladi and A. Timmis and C. Burchett and S. De-Beger and A. Nair and A. Banerjee and T. Fenton and S. D{\textquoteright}Costa and R. Bowker and C. Smith and V. Unsworth and Natarajan, {V. U.A.} and Wong, {L. Men} and P. Parslow and V. Kandala and S. Imran and S. Chandrasekaran and Ho, {S. A.} and I. Losa and K. Marinaki and N. Keenan and J. Nichols and J. Shippey and J. Iqbal and K. Watts and A. Yannoulias and Z. Huma and A. Sambo and L. Jadresic and S. Beames and D. Bockenhauer and D. Hothi and N. West and H. Price and M. Sinha and E. Neal and E. Reus and P. Sofocleous and I. Cannings and R. Sood and V. Mathew and E. Sharif and H. Bilolikar and S. White and T. Ayeni and R. O{\textquoteright}Connor and M. Eisenhut and T. Rajkowski and S. Clough and R. Dixon and K. Reep and K. Balasubramanian and H. Kisat and J. Cansick and J. Ellison and S. Smith and S. Tapscott and B. Oates and C. Bell and R. Shyam and E. Menzies and P. Cruickshanks and J. Schulga and C. Oxley and D. Hughes and A. Sharma and L. Krischock and J. Houston and D. Carroll and S. Goddard and E. Waxman and A. Webb and Saing, {T. T.} and C. Cunningham and A. Brown and V. Causer and D. Hughes and S. Taheri and A. Macdonald and T. McGregor and E. Carson and K. Riding and N. Thalange and C. Upton and L. Fear and G. Jones and V. Tandle and G. Osborne and M. Aslam and I. Norton and D. Dalton and K. Thattakkat and B. Wobi and B. Etuwewe and T. Walker and J. Browning and M. Carling and E. Killingbeck and D. Ryan and C. Tsvangirai-Mahachi and A. Lunn and M. Christian and Craze, {M. C.J.} and C. Derry and R. Jones and Sharman, {S. J.} and S. Wadams and H. Barham and S. Power and C. Tuffrey and S. Birch and J. Scanlan and A. Gribbin and S. McCready and A. Gordon and G. Boden and S. Hallett and C. Williams and G. Craig and H. Cottis and V. Lewis and C. McMillan and N. Osborne and C. Harrill and S. Wilkins and R. Kleta and L. Diskin and A. Billson and A. Barratt and G. Moss and S. Rhodes and A. Coupe and C. Moulds and M. Smith and S. Gilpin and J. Ratcliffe and S. Gardner and L. Chilukuri and Cooper, {L. C.C.} and S. Bennett and A. Petkar and A. Ul-Haq and G. Waring and R. Mann and N. Thorne and Z. Ibrahim and J. Buck and D. Beeby and E. Finlay and M. Allen and R. Mottram and K. Deakin and S. Johnson and Y. Tse and K. Bell and D. Chisholm and B. Padmakumar and T. Magadevan and M. Hughes and S. Rubin and A. Frary and S. Suri and S. El-Refee and C. Harrison and K. Davies and S. Kempson and N. Ayub and S. Mukhopadhyay and M. Crawford and M. Pervez and D. Thomas and G. Vemuri and R. Puttha and A. Setti and F. Al-Zidgali and C. Holliday and L. Woodhead",
year = "2018",
month = apr,
day = "1",
doi = "10.1007/s40273-017-0600-7",
language = "English",
volume = "36",
pages = "451--465",
journal = "Pharmacoeconomics",
issn = "1170-7690",
publisher = "Springer International Publishing",
number = "4",
}
