Mapping the Paediatric Quality of Life Inventory (PedsQL™) Generic Core Scales onto the Child Health Utility Index–9 Dimension (CHU-9D) Score for Economic Evaluation in Children

Tosin Lambe, Emma Frew, Natalie J. Ives, Rebecca L. Woolley, Carole Cummins, Elizabeth A. Brettell, Emma N. Barsoum, N. J.A. Webb, On behalf of the PREDNOS Trial Team, J. Ratcliffe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The Paediatric Quality of Life Inventory (PedsQL™) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost–utility analysis. The Child Health Utility Index–9 Dimension (CHU-9D), however, is a preference-based instrument that has been primarily developed to support cost–utility analysis. Objective: This paper presents a method for estimating CHU-9D index scores from responses to the PedsQL™ using data from a randomised controlled trial of prednisolone therapy for treatment of childhood corticosteroid-sensitive nephrotic syndrome. Methods: HRQoL data were collected from children at randomisation, week 16, and months 12, 18, 24, 36 and 48. Observations on children aged 5 years and older were pooled across all data collection timepoints and were then randomised into an estimation (n = 279) and validation (n = 284) sample. A number of models were developed using the estimation data before internal validation. The best model was chosen using multi-stage selection criteria. Results: Most of the models developed accurately predicted the CHU-9D mean index score. The best performing model was a generalised linear model (mean absolute error = 0.0408; mean square error = 0.0035). The proportion of index scores deviating from the observed scores by OpenSPiltSPi 0.03 was 53%. Conclusions: The mapping algorithm provides an empirical tool for estimating CHU-9D index scores and for conducting cost–utility analyses within clinical studies that have only collected PedsQL™ data. It is valid for children aged 5 years or older. Caution should be exercised when using this with children younger than 5 years, older adolescents (CloseSPigtSPi 13 years) or patient groups with particularly poor quality of life. ISRCTN Registry No: 16645249.

Original languageEnglish
Pages (from-to)451-465
Number of pages15
JournalPharmacoeconomics
Volume36
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018
Externally publishedYes

Keywords

  • PedsQL
  • Paediatric Quality of Life Inventory
  • health-related quality of life
  • Child Health Utility Index

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    Lambe, T., Frew, E., Ives, N. J., Woolley, R. L., Cummins, C., Brettell, E. A., Barsoum, E. N., Webb, N. J. A., On behalf of the PREDNOS Trial Team, & Ratcliffe, J. (2018). Mapping the Paediatric Quality of Life Inventory (PedsQL™) Generic Core Scales onto the Child Health Utility Index–9 Dimension (CHU-9D) Score for Economic Evaluation in Children. Pharmacoeconomics, 36(4), 451-465. https://doi.org/10.1007/s40273-017-0600-7