Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

Vicki Edwards, Kirsten Benkendorff, Fiona Young

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 μM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC's occurred after 4 h at 391 μM tyrindoleninone compared to 20 μM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.

    Original languageEnglish
    Pages (from-to)64-83
    Number of pages20
    JournalMarine Drugs
    Volume10
    Issue number1
    DOIs
    Publication statusPublished - Jan 2012

    Keywords

    • Apoptosis
    • Brominated indoles
    • Gynaecological cancers
    • Marine mollusc

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