Marine viruses discovered via metagenomics shed light on viral strategies throughout the oceans

Felipe H. Coutinho; Cynthia B. Silveira; Gustavo B. Gregoracci; Cristiane C. Thompson; Robert A. Edwards; Corina P.D. Brussaard; Bas E. Dutilh; Fabiano L. Thompson

doi:10.1038/ncomms15955

Marine viruses discovered via metagenomics shed light on viral strategies throughout the oceans

Felipe H. Coutinho, Cynthia B. Silveira, Gustavo B. Gregoracci, Cristiane C. Thompson, Robert A. Edwards, Corina P.D. Brussaard, Bas E. Dutilh, Fabiano L. Thompson

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Abstract

Marine viruses are key drivers of host diversity, population dynamics and biogeochemical cycling and contribute to the daily flux of billions of tons of organic matter. Despite recent advancements in metagenomics, much of their biodiversity remains uncharacterized. Here we report a data set of 27,346 marine virome contigs that includes 44 complete genomes. These outnumber all currently known phage genomes in marine habitats and include members of previously uncharacterized lineages. We designed a new method for host prediction based on co-occurrence associations that reveals these viruses infect dominant members of the marine microbiome such as Prochlorococcus and Pelagibacter. A negative association between host abundance and the virus-to-host ratio supports the recently proposed Piggyback-the-Winner model of reduced phage lysis at higher host densities. An analysis of the abundance patterns of viruses throughout the oceans revealed how marine viral communities adapt to various seasonal, temperature and photic regimes according to targeted hosts and the diversity of auxiliary metabolic genes.

Original language	English
Article number	15955
Number of pages	12
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15955
Publication status	Published - 5 Jul 2017
Externally published	Yes

Bibliographical note

This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Keywords

Marine biology
Metagenomics
Microbial ecology
Water microbiology

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Coutinho_Marine_P2017Final published version, 1.61 MBLicence: CC BY

Cite this

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abstract = "Marine viruses are key drivers of host diversity, population dynamics and biogeochemical cycling and contribute to the daily flux of billions of tons of organic matter. Despite recent advancements in metagenomics, much of their biodiversity remains uncharacterized. Here we report a data set of 27,346 marine virome contigs that includes 44 complete genomes. These outnumber all currently known phage genomes in marine habitats and include members of previously uncharacterized lineages. We designed a new method for host prediction based on co-occurrence associations that reveals these viruses infect dominant members of the marine microbiome such as Prochlorococcus and Pelagibacter. A negative association between host abundance and the virus-to-host ratio supports the recently proposed Piggyback-the-Winner model of reduced phage lysis at higher host densities. An analysis of the abundance patterns of viruses throughout the oceans revealed how marine viral communities adapt to various seasonal, temperature and photic regimes according to targeted hosts and the diversity of auxiliary metabolic genes.",

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Marine viruses discovered via metagenomics shed light on viral strategies throughout the oceans

Abstract

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Keywords

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