TY - JOUR
T1 - Maternal diet and offspring telomere length
T2 - a systematic review
AU - Habibi, Nahal
AU - Bianco-Miotto, Tina
AU - Phoi, Yan Yin
AU - Jankovic-Karasoulos, Tanja
AU - Roberts, Claire T.
AU - Grieger, Jessica A.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - CONTEXT: Many studies assert a negative influence of inappropriate maternal diet and nutritional status during pregnancy on offspring, not only in utero but throughout life, because of the role in the programing of noncommunicable diseases. Telomere length is a biomarker of aging, and shorter telomeres are associated with chronic disease later in life. Maternal nutrition and nutritional status may be an important determinant of offspring telomere length. OBJECTIVE: A systematic review was conducted to determine the effect of maternal nutrition and nutritional status in pregnancy on offspring telomere length. DATA SOURCES: This systematic review was conducted according to PRISMA guidelines. Database searches of PubMed, CINAHL, Scopus, Medline, and Web of Science were performed. STUDY SELECTION: Included studies assessed the association between maternal nutrition (dietary intake and nutritional status) during pregnancy and offspring telomere length measured in cord blood, serum, plasma, and peripheral blood mononuclear cells. DATA EXTRACTION: Three authors screened and determined the quality of the articles; disagreements were resolved by a fourth author. All authors compared the compiled data. RESULTS: Seven studies were extracted and evaluated. Studies comprised a double-blind placebo-controlled trial (n = 1), prospective cohort studies (n = 5), and a cross-sectional study (n = 1). Higher circulating maternal folate and 25-hydroxyvitamin D3 concentrations, along with higher maternal dietary caffeine intakes, were associated with longer offspring telomere length, whereas higher dietary intake of carbohydrate, folate, n-3 polyunsaturated fatty acids, vitamin C, or sodium was not. CONCLUSION: The limited but suggestive evidence highlights the need for further research to be conducted in this area, particularly longitudinal studies involving larger cohorts of pregnant women. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42019136506.
AB - CONTEXT: Many studies assert a negative influence of inappropriate maternal diet and nutritional status during pregnancy on offspring, not only in utero but throughout life, because of the role in the programing of noncommunicable diseases. Telomere length is a biomarker of aging, and shorter telomeres are associated with chronic disease later in life. Maternal nutrition and nutritional status may be an important determinant of offspring telomere length. OBJECTIVE: A systematic review was conducted to determine the effect of maternal nutrition and nutritional status in pregnancy on offspring telomere length. DATA SOURCES: This systematic review was conducted according to PRISMA guidelines. Database searches of PubMed, CINAHL, Scopus, Medline, and Web of Science were performed. STUDY SELECTION: Included studies assessed the association between maternal nutrition (dietary intake and nutritional status) during pregnancy and offspring telomere length measured in cord blood, serum, plasma, and peripheral blood mononuclear cells. DATA EXTRACTION: Three authors screened and determined the quality of the articles; disagreements were resolved by a fourth author. All authors compared the compiled data. RESULTS: Seven studies were extracted and evaluated. Studies comprised a double-blind placebo-controlled trial (n = 1), prospective cohort studies (n = 5), and a cross-sectional study (n = 1). Higher circulating maternal folate and 25-hydroxyvitamin D3 concentrations, along with higher maternal dietary caffeine intakes, were associated with longer offspring telomere length, whereas higher dietary intake of carbohydrate, folate, n-3 polyunsaturated fatty acids, vitamin C, or sodium was not. CONCLUSION: The limited but suggestive evidence highlights the need for further research to be conducted in this area, particularly longitudinal studies involving larger cohorts of pregnant women. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42019136506.
KW - cord blood
KW - folate
KW - maternal diet
KW - maternal nutritional status
KW - offspring
KW - pregnancy
KW - telomere length
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85099721813&partnerID=8YFLogxK
U2 - 10.1093/nutrit/nuaa097
DO - 10.1093/nutrit/nuaa097
M3 - Article
C2 - 32968801
AN - SCOPUS:85099721813
VL - 79
SP - 148
EP - 159
JO - Nutrition reviews
JF - Nutrition reviews
SN - 1753-4887
IS - 2
ER -