Maternal Obesity and the Early Origins of Childhood Obesity: Weighing up the Benefits and Costs of Maternal Weight Loss in the Periconceptional Period for the Offspring

Song Zhang, Leewen Rattanatray, Janna Morrison, Lisa Nicholas, Shervi Lie, I Caroline McMillen

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Abstract

    There is a need to understand the separate or interdependent contributions of maternal prepregnancy BMI, gestational weight gain, glycaemic control, and macronutrient intake on the metabolic outcomes for the offspring. Experimental studies highlight that there may be separate influences of maternal obesity during the periconceptional period and late gestation on the adiposity of the offspring. While a period of dietary restriction in obese mothers may ablate the programming of obesity, it is associated with an activation of the stress axis in the offspring. Thus, maternal obesity may result in epigenetic changes which predict the need for efficient fat storage in postnatal life, while maternal weight loss may lead to epigenetic changes which predict later adversity. Thus, development of dietary interventions for obese mothers during the periconceptional period requires a greater evidence base which allows the effective weighing up of the metabolic benefits and costs for the offspring.

    Original languageEnglish
    Article number585749
    Number of pages10
    JournalExp Diabetes Res
    Volume2011
    Issue number585749
    DOIs
    Publication statusPublished - 2011

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