TY - JOUR
T1 - Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision
AU - Lu, Jean C.
AU - Vogrin, Sara
AU - McAuley, Sybil A.
AU - Lee, Melissa H.
AU - Paldus, Barbora
AU - Bach, Leon A.
AU - Burt, Morton G.
AU - Clarke, Philip M.
AU - Cohen, Neale D.
AU - Colman, Peter G.
AU - de Bock, Martin I.
AU - Jane Holmes-Walker, D.
AU - Jenkins, Alicia J.
AU - Kaye, Joey
AU - Keech, Anthony C.
AU - Kumareswaran, Kavita
AU - MacIsaac, Richard J.
AU - McCallum, Roland W.
AU - Roem, Kerryn
AU - Sims, Catriona
AU - Stranks, Stephen N.
AU - Trawley, Steven
AU - Ward, Glenn M.
AU - Sundararajan, Vijaya
AU - Jones, Timothy W.
AU - O'Neal, David N.
AU - Australian JDRF Closed-Loop Research Group
AU - Speight, Jane
AU - Hendrieckx, Christel
AU - Halliday, Jennifer
AU - Russell-Green, Sienna
AU - Januszewski, Andrzej
AU - Husin, Hanafi Mohamad
AU - Davis, Elizabeth A.
AU - Abraham, Mary B.
AU - Ambler, Geoffrey R.
AU - Cameron, Fergus J.
AU - Fairchild, Jan M.
AU - King, Bruce R.
PY - 2021/9
Y1 - 2021/9
N2 - Aims: To compare meal-time glycaemia in adults with type 1 diabetes mellitus (T1D) managed with multiple daily injections (MDI) vs. insulin pump therapy (IPT), using self-monitoring blood glucose (SMBG), following diabetes education. Methods: Adults with T1D received carbohydrate-counting education and a bolus calculator: MDI (Roche Aviva Expert) and IPT (pump bolus calculator). All then wore 3-weeks of masked-CGM (Enlite, Medtronic). Meal-times were assessed by two approaches: 1) Set time-blocks (breakfast 06:00–10:00hrs; lunch 11:00–15:00hrs; dinner 17:00–21:00hrs) and 2) Bolus-calculator carbohydrate entries signalling meal commencement. Post-meal masked-CGM time-in-range (TIR) 3.9–10.0 mmol/L was the primary outcome. Results: MDI(n = 61) and IPT (n = 59) participants were equivalent in age, sex, diabetes duration and HbA1c. Median (IQR) education time provided did not differ (MDI: 1.1 h (0.75, 1.5) vs. IPT: 1.1 h (1.0, 2.0); p = 0.86). Overall, daytime (06:00–24:00hrs), lunch and dinner TIR did not differ for MDI vs. IPT participants but was greater for breakfast with IPT in both analyses with a mean difference of 12.8%, (95 CI 4.8, 20.9); p = 0.002 (time-block analysis). Conclusion: After diabetes education, MDI and IPT use were associated with similar day-time glycemia, though IPT users had significantly greater TIR during the breakfast period. With education, meal-time glucose levels are comparable with use of MDI vs. pumps.
AB - Aims: To compare meal-time glycaemia in adults with type 1 diabetes mellitus (T1D) managed with multiple daily injections (MDI) vs. insulin pump therapy (IPT), using self-monitoring blood glucose (SMBG), following diabetes education. Methods: Adults with T1D received carbohydrate-counting education and a bolus calculator: MDI (Roche Aviva Expert) and IPT (pump bolus calculator). All then wore 3-weeks of masked-CGM (Enlite, Medtronic). Meal-times were assessed by two approaches: 1) Set time-blocks (breakfast 06:00–10:00hrs; lunch 11:00–15:00hrs; dinner 17:00–21:00hrs) and 2) Bolus-calculator carbohydrate entries signalling meal commencement. Post-meal masked-CGM time-in-range (TIR) 3.9–10.0 mmol/L was the primary outcome. Results: MDI(n = 61) and IPT (n = 59) participants were equivalent in age, sex, diabetes duration and HbA1c. Median (IQR) education time provided did not differ (MDI: 1.1 h (0.75, 1.5) vs. IPT: 1.1 h (1.0, 2.0); p = 0.86). Overall, daytime (06:00–24:00hrs), lunch and dinner TIR did not differ for MDI vs. IPT participants but was greater for breakfast with IPT in both analyses with a mean difference of 12.8%, (95 CI 4.8, 20.9); p = 0.002 (time-block analysis). Conclusion: After diabetes education, MDI and IPT use were associated with similar day-time glycemia, though IPT users had significantly greater TIR during the breakfast period. With education, meal-time glucose levels are comparable with use of MDI vs. pumps.
KW - Diabetes Mellitus
KW - Glycaemia
KW - Insulin pumps
KW - insulin
UR - http://www.scopus.com/inward/record.url?scp=85113686780&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1099379
U2 - 10.1016/j.diabres.2021.109000
DO - 10.1016/j.diabres.2021.109000
M3 - Article
AN - SCOPUS:85113686780
SN - 0168-8227
VL - 179
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 109000
ER -
