Measurement of human dopamine β hydroxylase in serum by homologous radioimmunoassay

R. A. Rush, P. E. Thomas, S. Udenfriend

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Human serum dopamine β hydroxylase [3,4 dihydroxyphenylethylamine, ascorbate: oxygen oxidoreductase (β hydroxylating), EC] levels were determined in 52 examples with a newly devised radioimmunoassay that utilizes purified human enzyme and its specific antiserum. The values obtained were in excellent agreement (correlation coefficient r= 0.98) with those obtained by measuring enzymatic activity in the same sera. Either assay technique, enzymatic or homologous radioimmunoassay, can be used for measurement of the enzyme in normal human serum.

Original languageEnglish
Pages (from-to)750-752
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number2
Publication statusPublished - Feb 1975
Externally publishedYes


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